臺大公衛學院-公共衛生學系;臺大公衛學院-預防醫學研究所;臺大醫院;臺大醫院-內科部;臺大醫院雲林分院;臺大醫學院-臨床醫學研究所;YING-CHUEN LAIHUNG-YUAN LICHI-SHENG HUNGMAO-SHIN LINSHYANG-RONG SHIHMa, W. -Y.W. -Y.MaHua, C. -H.C. -H.HuaLEE-MING CHUANGSung, F. -C.F. -C.SungWei, J. -N.J. -N.Wei2014-02-142018-07-112014-02-142018-07-112013-03http://ntur.lib.ntu.edu.tw//handle/246246/259242https://pubmed.ncbi.nlm.nih.gov/22946586/Diabet. Med. 30, 318325 (2013) Abstract Aims To evaluate whether homeostasis model assessment and high-sensitivity C-reactive protein improve the prediction of isolated post-load hyperglycaemia. Methods The subjects were 1458 adults without self-reported diabetes recruited between 2006 and 2010. Isolated post-load hyperglycaemia was defined as fasting plasma glucose <7mmol/l and 2-h post-load plasma glucose 11.1mmol/l. Risk scores of isolated post-load hyperglycaemia were constructed by multivariate logistic regression. An independent group (n=154) was enrolled from 2010 to 2011 to validate the models' performance. Results One hundred and twenty-three subjects (8.28%) were newly diagnosed as having diabetes mellitus. Among those with undiagnosed diabetes, 64 subjects (52%) had isolated post-load hyperglycaemia. Subjects with isolated post-load hyperglycaemia were older, more centrally obese and had higher blood pressure, HbA1c, fasting plasma glucose, triglycerides, LDL cholesterol, high-sensitivity C-reactive protein and homeostasis model assessment of insulin resistance and lower homeostasis model assessment of -cell function than those without diabetes. The risk scores included age, gender, BMI, homeostasis model assessment, high-sensitivity C-reactive protein and HbA1c. The full model had high sensitivity (84%) and specificity (87%) and area under the receiver operating characteristic curve (0.91), with a cut-off point of 23.81; validation in an independent data set showed 88% sensitivity, 77% specificity and an area under curve of 0.89. Conclusions Over half of those with undiagnosed diabetes had isolated post-load hyperglycaemia. Homeostasis model assessment and high-sensitivity C-reactive protein are useful to identify subjects with isolated post-load hyperglycaemia, with improved performance over fasting plasma glucose or HbA1c alone.99 bytestext/htmlen[SDGs]SDG3journal article10.1111/dme.1200822946586http://ntur.lib.ntu.edu.tw/bitstream/246246/259242/1/index.html