Tian X.LING-WEI HSINWebster E.L.Contoreggi C.Chrousos G.P.Gold P.W.Habib K.Ayala A.Eckelman W.C.Jacobson A.E.Rice K.C.2021-07-072021-07-0720010960894Xhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0035847696&doi=10.1016%2fS0960-894X%2800%2900661-2&partnerID=40&md5=a21f1243eedfa40940373f558ce6b258https://scholars.lib.ntu.edu.tw/handle/123456789/570500A high-affinity radioligand for CRHR1 has been prepared that can serve as a template for the development of SPECT imaging agents. The 5-chloro-N-cyclopropylmethyl-N-(2,6-dichloro-4-iodophenyl)-2-methyl-N-propylp yrimidine-4,6-diamine (6b, Ki = 14 nM), and the corresponding 4-bromophenyl analogue (6a, Ki = 21 nM), were synthesized in four steps from compound 3.journal article10.1016/S0960-894X(00)00661-2112121032-s2.0-0035847696