Wang I.-J.CHIA-YANG CHENBornehag C.-G.2022-03-232022-03-2320161438-4639https://www.scopus.com/inward/record.uri?eid=2-s2.0-84960492465&doi=10.1016%2fj.ijheh.2015.12.001&partnerID=40&md5=a8b1900dc4133f2b2b830394d74c0a72https://scholars.lib.ntu.edu.tw/handle/123456789/601714Background: Little is known about the effect of Bisphenol A (BPA) on atopic disorders. Objective: To investigated the associations (i) between postnatal BPA exposure and allergic diseases in children; (ii) between BPA and IgE levels for the possible disease pathogenesis; and (iii) gender-based differences. Methods: A total of 453 children from Childhood Environment and Allergic Diseases Study cohort with urine and blood samples were recruited in Taiwan. Urinary BPA glucoronide (BPAG) levels were measured by UPLC-MS/MS at ages 3 and 6 years. The associations between BPAG levels at different ages and IgE levels and the development of allergic diseases were evaluated by multivariate linear regression and logistic regression. A mediation analysis was also conducted to evaluate how much risk of allergic diseases in relation to BPA exposure is explained by IgE changes. Results: The BPAG levels at age 3 were positively associated with IgE levels at age 3 (β = 64.85 kU/l per ln-unit increase BPAG level; 95% CI, 14.59-115.11 kU/l). Stratified by gender, BPAG levels at age 3 were positively associated with IgE levels at age 3, particularly in girls (β = 139.23 kU/l; 95% CI, 57.38-221.09 kU/l). Similar results were also found at age 6. Urinary BPAG levels at age 3 were significantly associated with asthma at ages 3 and 6, with OR (95%CI) of 1.29(1.08-1.55) and 1.27(1.04-1.55). We estimated that 70% of the total effect of BPA exposure on asthma is mediated by IgE levels. Conclusions: BPA exposures were associated with IgE levels and may increase the risk of development of allergic diseases in children particularly in girls.[SDGs]SDG3[SDGs]SDG6journal article10.1016/j.ijheh.2015.12.001267650872-s2.0-84960492465