2017-05-012024-05-18https://scholars.lib.ntu.edu.tw/handle/123456789/712049摘要：本計畫將開發微型多點生理訊號偵測探針，以利在心臟手術中手術醫師能透過同時多點偵測組織的鈉、鉀、鈣、氨等離子濃度及酸鹼值和溫度。並藉此判斷心肌保護的好壞以及預防術後心臟功能因數中保護不佳而受損。此外，週邊動脈阻塞造成肌肉組織缺血的機制與表現類似於心肌，故我們亦同時設計並執行動物及人體實驗來驗證該多點生理訊號偵測探針在週邊動脈阻塞疾病偵測肌肉缺血的有效性。目前臨床上並沒有一種簡單有效又快速的方法在手術中心臟停止的情況下偵測心肌保護的效果的好壞。在現今的心臟手術中，只有在心臟復跳後其收縮力或是節律不穩定時，術者才能了解到心肌的保護也許並不理想。該探針將協助醫師找出一種簡單的方法，在心臟的收縮及電氣活動都停止的狀態下仍可以偵測心肌保護是否適當，需要時使外科醫師能及時採取必要措施來加強心肌的保護。為實現該探針的開發，本計畫共包含四項子計畫從執行動物及人體實驗驗證、微型探針實體設計與製做、無線感測微系統晶片包括無線電源模組、訊號處理模組及無線訊號發射模組與感測材料之製程配方。希冀透過整合與動物實驗與臨床驗證，將此具有低成本、多功能、微型之生理訊號檢測探針開發成功，提供醫師心臟術中多模式診治技術之應用。<br> Abstract: The project is aimed at the development of a miniature multipoint physiological signal detection probe, MPSDP, to help surgeons to do the intraoperative heart muscle monitoring. Via the multipoint detections the concentration of sodium, potassium, calcium, ammonia and pH and temperature in the muscle, doctors can effectively determine the quality of myocardial protection and prevention of postoperative cardiac function factor in the poor protection and damage. In addition, peripheral arterial occlusion resulting from the mechanism of muscle tissue ischemia and performance similar to the heart behavior, so the verification of the MPSDP will also be performed for the application of peripheral arterial occlusive disease detection in muscle ischemia with both animal and human studies. At present, there is no simple, effective and rapid method to detect the effect of myocardial protection in the case of cardiac arrest. In today`s cardiac surgery, only after cardiac resuscitation or rhythm of its instability, the surgeon can understand whether the protection of the heart is well performed. The success of this project can facilitate the probe to assist the physician in finding an easy way to detect the adequacy of myocardial protection in the event of cardiac contraction and electrical activity being stopped, allow the surgeon to take the necessary measures in time to enhance protection of the myocardium. In order to realize the development of the probe, the project comprises four subprojects from the implementation of animal and human experiments to verify the physical, design and manufacture of micro-probe, wireless sensing micro-system chip, including wireless power module, signal processing module and the wireless signal transmission module, and the sensing material process formula development. It can be expected that the low-cost, multi-functional, miniature MPSDP can potentially provide physician multi-mode diagnosis and treatment technology in the cardiac surgery through the integration with animal experiments and clinical validation.多點生理訊號偵測微型探針感測電路MPSDPsensor interface