Chen, Chien-TienChien-TienChenLin, Jin-ShengJin-ShengLinKuo, Jen-HuangJen-HuangKuoWeng, Shiue-ShienShiue-ShienWengCuo, Ting-ShenTing-ShenCuoLin, Yi-WenYi-WenLinCheng, Chien-ChungChien-ChungChengHuang, Yan-ChenYan-ChenHuangYu, Jen-KanJen-KanYuChou, Pi-TaiPi-TaiChou2009-09-092018-07-102009-09-092018-07-102004http://ntur.lib.ntu.edu.tw//handle/246246/164774http://ntur.lib.ntu.edu.tw/bitstream/246246/164774/1/30.pdf(Chemical equation presented) The titled vanadyl(V) complexes serve as efficient reagents for cleaving supercoiled plasmid DNA by photoinitiation. Complex 3d, derived from 2-hydroxy-1-naphthaldehyde and L-phenylalanine, exhibits a unique wedge feature, inducing a site-selective photocleavage at the C22-T23 of the bulge backbone for a HIV-27 DNA system at 0.1-5 μM. Transient absorption experiments for 3d indicate the involvement of LMCT with concomitant tautomerization, leading to an o-quinone-methide V-bound hydroxyl species responsible for the cleavage profiles.application/pdf186545 bytesapplication/pdfen-US[SDGs]SDG3[SDGs]SDG152 hydroxy 1 naphthaldehyde; aldehyde derivative; amino acid derivative; antineoplastic agent; antivirus agent; hydroxyl group; phenylalanine; plasmid DNA; quinone derivative; reagent; unclassified drug; vanadyl derivative; absorption; antineoplastic activity; antiviral activity; article; complex formation; derivatization; DNA cleavage; DNA supercoiling; drug activity; drug mechanism; photodynamics; site directed mutagenesis; Base Sequence; DNA; HIV Long Terminal Repeat; Models, Molecular; Photolysis; Plasmids; Vanadium Compoundsjournal article10.1021/ol048156hhttp://ntur.lib.ntu.edu.tw/bitstream/246246/164774/1/30.pdf