Armario, XavierXavierArmarioCarron, JenniferJenniferCarronSimpkin, Andrew JAndrew JSimpkinElhadi, MohamedMohamedElhadiKennedy, CiaraCiaraKennedyAbdel-Wahab, MohamedMohamedAbdel-WahabBleiziffer, SabineSabineBleizifferLefèvre, ThierryThierryLefèvreWolf, AlexanderAlexanderWolfPilgrim, ThomasThomasPilgrimVillablanca, Pedro APedro AVillablancaBlackman, Daniel JDaniel JBlackmanVan Mieghem, Nicolas MNicolas MVan MieghemHengstenberg, ChristianChristianHengstenbergSwaans, Martin JMartin JSwaansPrendergast, Bernard DBernard DPrendergastPatterson, TiffanyTiffanyPattersonBarbanti, MarcoMarcoBarbantiWebb, John GJohn GWebbBehan, MilesMilesBehanResar, JonJonResarChen, MaoMaoChenHildick-Smith, DavidDavidHildick-SmithSpence, Mark SMark SSpenceZweiker, DavidDavidZweikerBagur, RodrigoRodrigoBagurTeles, RuiRuiTelesRibichini, Flavio LFlavio LRibichiniJagielak, DariuszDariuszJagielakPark, Duk-WooDuk-WooParkKornowski, RanRanKornowskiWykrzykowska, Joanna JJoanna JWykrzykowskaBunc, MatjazMatjazBuncEstévez-Loureiro, RodrigoRodrigoEstévez-LoureiroPoon, KarlKarlPoonGötberg, MatthiasMatthiasGötbergJeger, Raban VRaban VJegerInce, HüseyinHüseyinIncePacker, Erik J SErik J SPackerAngelillis, MarcoMarcoAngelillisNombela-Franco, LuisLuisNombela-FrancoGuo, YingqiangYingqiangGuoSavontaus, MikkoMikkoSavontausAl-Moghairi, Abdulrahman MAbdulrahman MAl-MoghairiParasca, Catalina AndreeaCatalina AndreeaParascaKliger, ChadChadKligerRoy, DavidDavidRoyMolnár, LeventeLeventeMolnárSilva, MarianaMarianaSilvaWhite, JonathonJonathonWhiteYamamoto, MasanoriMasanoriYamamotoCarrilho-Ferreira, PedroPedroCarrilho-FerreiraToggweiler, StefanStefanToggweilerVoudris, VassileiosVassileiosVoudrisOhno, YoheiYoheiOhnoRodrigues, InêsInêsRodriguesParma, RadosławRadosławParmaOjeda, SoledadSoledadOjedaToutouzas, KostasKostasToutouzasRegueiro, AnderAnderRegueiroGrygier, MarekMarekGrygierAlMerri, KhaledKhaledAlMerriCruz-González, IgnacioIgnacioCruz-GonzálezFridrich, ViliamViliamFridrichde la Torre Hernández, José MJosé Mde la Torre HernándezNoble, StephaneStephaneNobleKala, PetrPetrKalaAsmarats, LluisLluisAsmaratsKurt, Ibrahim HalilIbrahim HalilKurtBosmans, JohanJohanBosmansErglis, MartinsMartinsErglisCasserly, IvanIvanCasserlyIskandarani, DouniaDouniaIskandaraniBhindi, RavinayRavinayBhindiKefer, JoelleJoelleKeferYin, Wei-HsianWei-HsianYinRosseel, LiesbethLiesbethRosseelKim, Hyo-SooHyo-SooKimO'Connor, StephenStephenO'ConnorHellig, FarrelFarrelHelligSztejfman, MatiasMatiasSztejfmanMendiz, OscarOscarMendizPineda, Andres MAndres MPinedaSeth, AshokAshokSethPllaha, EltonEltonPllahade Brito, Fabio SFabio Sde BritoBajoras, VilhelmasVilhelmasBajorasBalghith, Mohammed AMohammed ABalghithLee, MichaelMichaelLeeEid-Lidt, GueringGueringEid-LidtVandeloo, BertBertVandelooVaz, Vinicius DaherVinicius DaherVazAlasnag, MirvatMirvatAlasnagUssia, Gian PaoloGian PaoloUssiaTay, EdgarEdgarTayMayol, JorgeJorgeMayolGunasekaran, SengottuveluSengottuveluGunasekaranSardella, GennaroGennaroSardellaBuddhari, WacinWacinBuddhariHSIEN-LI KAODager, AntonioAntonioDagerTzikas, ApostolosApostolosTzikasGudmundsdottir, Ingibjörg JIngibjörg JGudmundsdottirEdris, AhmadAhmadEdrisGutiérrez Jaikel, Luis AbelLuis AbelGutiérrez JaikelArias, Eduardo AEduardo AAriasAl-Hijji, MohammedMohammedAl-HijjiErtürk, MehmetMehmetErtürkConde-Vela, CésarCésarConde-VelaBoljević, DarkoDarkoBoljevićFerrero Guadagnoli, AdolfoAdolfoFerrero GuadagnoliHermlin, ToomasToomasHermlinElGuindy, Ahmed MAhmed MElGuindyLima-Filho, Moysés de OliveiraMoysés de OliveiraLima-Filhode Moura Santos, LucianoLucianode Moura SantosPerez, LuisLuisPerezMaluenda, GabrielGabrielMaluendaAkyüz, Ali RızaAli RızaAkyüzAlhaddad, Imad AImad AAlhaddadAmin, HaithamHaithamAminSo, Chak-YuChak-YuSoAl Nooryani, Arif AArif AAl NooryaniVaca, CarlosCarlosVacaAlbistur, JuanJuanAlbisturNguyen, Quang NgocQuang NgocNguyenArzamendi, DabitDabitArzamendiGrube, EberhardEberhardGrubeModine, ThomasThomasModineTchétché, DidierDidierTchétchéHayashida, KentaroKentaroHayashidaLatib, AzeemAzeemLatibMakkar, Raj RRaj RMakkarPiazza, NicoloNicoloPiazzaSøndergaard, LarsLarsSøndergaardMcEvoy, John WilliamJohn WilliamMcEvoyMylotte, DarrenDarrenMylotte2025-01-082025-01-082024-02-12https://pubmed.ncbi.nlm.nih.gov/38180419/https://scholars.lib.ntu.edu.tw/handle/123456789/724656The COVID-19 pandemic adversely affected health care systems. Patients in need of transcatheter aortic valve replacement (TAVR) are especially susceptible to treatment delays. This study sought to evaluate the impact of the COVID-19 pandemic on global TAVR activity. This international registry reported monthly TAVR case volume in participating institutions prior to and during the COVID-19 pandemic (January 2018 to December 2021). Hospital-level information on public vs private, urban vs rural, and TAVR volume was collected, as was country-level information on socioeconomic status, COVID-19 incidence, and governmental public health responses. We included 130 centers from 61 countries, including 65,980 TAVR procedures. The first and second pandemic waves were associated with a significant reduction of 15% (P < 0.001) and 7% (P < 0.001) in monthly TAVR case volume, respectively, compared with the prepandemic period. The third pandemic wave was not associated with reduced TAVR activity. A greater reduction in TAVR activity was observed in Africa (-52%; P = 0.001), Central-South America (-33%; P < 0.001), and Asia (-29%; P < 0.001). Private hospitals (P = 0.005), urban areas (P = 0.011), low-volume centers (P = 0.002), countries with lower development (P < 0.001) and economic status (P < 0.001), higher COVID-19 incidence (P < 0.001), and more stringent public health restrictions (P < 0.001) experienced a greater reduction in TAVR activity. TAVR procedural volume declined substantially during the first and second waves of the COVID-19 pandemic, especially in Africa, Central-South America, and Asia. National socioeconomic status, COVID-19 incidence, and public health responses were associated with treatment delays. This information should inform public health policy in case of future global health crises.enaortic valve stenosiscoronavirus disease 2019transcatheter aortic valve replacementvalvular heart disease[SDGs]SDG3journal article10.1016/j.jcin.2023.10.04138180419