Ho, Tsung-ChuanTsung-ChuanHoTsai, Shawn HShawn HTsaiYeh, Shu-IShu-IYehSHOW-LI CHENTung, Kwang-YiKwang-YiTungChien, Hsin-YuHsin-YuChienLu, Yung-ChangYung-ChangLuHuang, Chang-HungChang-HungHuangTsao, Yeou-PingYeou-PingTsao2019-08-302019-08-302019-01-031757-6512https://scholars.lib.ntu.edu.tw/handle/123456789/416916https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059502619&doi=10.1186%2fs13287-018-1110-z&partnerID=40&md5=8b1eaf9c55bdd85da7b0e8e9fcd84c15Tendon stem/progenitor cells (TSPC) exhibit a low proliferative response to heal tendon injury, leading to limited regeneration outcomes. Exogenous growth factors that activate TSPC proliferation have emerged as a promising approach for treatment. Here, we evaluated the pigment epithelial-derived factor (PEDF)-derived short peptide (PSP; 29-mer) for treating acute tendon injury and to determine the timing and anatomical features of CD146- and necleostemin-positive TSPC in the tendon healing process.enPEDF; Peptide; Signaling; Tendon stem/progenitor cell[SDGs]SDG3alginic acid; broxuridine; CD146 antigen; cell protein; collagen type 1; collagen type 3; growth factor; mitogen activated protein kinase 1; nestin; nucleostemin; octamer transcription factor 4; pigment epithelium derived factor derived short peptide; STAT3 protein; unclassified drug; eye protein; nerve growth factor; peptide; pigment epithelium-derived factor; serine proteinase inhibitor; achilles tendon rupture; adult; animal cell; animal experiment; animal model; animal tissue; Article; biomechanics; cell differentiation; cell infiltration; cell proliferation; cell stimulation; cellular distribution; clonogenesis; collagen fiber; colony formation; controlled study; drug efficacy; healing; immunohistochemistry; male; mitogenesis; New Zealand White (rabbit); nonhuman; priority journal; protein analysis; protein expression; protein phosphorylation; rat; stem cell; stem cell expansion; stem cell niche; sustained drug release; tendon healing; tendon stem cell; tenocyte; tensile strength; tissue regeneration; Western blotting; wound healing; achilles tendon; animal; cytology; genetics; human; Leporidae; metabolism; pathophysiology; regeneration; stem cell; tendon injury; Achilles Tendon; Animals; Eye Proteins; Humans; Nerve Growth Factors; Peptides; Rabbits; Rats; Regeneration; Serpins; Stem Cells; Tendon Injuriesjournal articlehttps://api.elsevier.com/content/abstract/scopus_id/8505950261910.1186/s13287-018-1110-z306062212-s2.0-85059502619WOS:000454902400002https://api.elsevier.com/content/abstract/scopus_id/85059502619