李芝珊2006-07-252018-06-302006-07-252018-06-302005-07-31http://ntur.lib.ntu.edu.tw//handle/246246/4888為達到對感染性病毒氣膠去活化之目 的， 紫外線之應用也就非常普遍。本研究 在實驗室測試腔評估紫外線對空氣以及表 面病毒的去活化效率， 評估不同紫外線劑 量、不同的病毒核酸形式以及不同的相對 濕度對於病毒去活化效率之影響。對空氣 中病毒來說， 紫外線欲去除百分之九十之 單股RNA病毒以及雙股RNA病毒別需要劑 量339-423 μ W sec/cm2 和662-863 μW sec/cm2。同時本研究也發現， 欲對空氣以 及表面病毒達到百分之九十九之去除效率 所需之紫外線劑量為百分之九十去除效率 之兩倍。另外， 在相同病毒去除效率下， 表面上的病毒所需之紫外線劑量為空氣中 病毒的3.9至7.6倍。不論是空氣中或表面 上的病毒， 單股核酸病毒均比雙股核酸病 毒對紫外線具有較佳之感受性。在相對濕 度85 %時， 紫外線對於病毒去活化效果較 相對濕度55 %差， 可能的原因是水氣附著 於病毒表面遮蔽部分UVGI， 導致RNA病 毒在高相對濕度下， 對紫外線之感受性降 低。由以上結果可知， 紫外線對於病毒來 說具有非常好的去活化效果。The increasing incidence of infectious diseases has prompted the application of Ultraviolet Germicidal Irradiation (UVGI) for the inactivation of viruses. This study evaluates UVGI effectiveness for both airborne and surface viruses in a laboratory test chamber by determining the effect of UV dosage, different nucleic acid type of virus, and relative humidity on virus survival fraction after UVGI exposure. For airborne viruses, the UVGI dose for 90% inactivation was 339-423 μ W sec/cm2 for ssRNA, and 662-863 μ W sec/cm2 for dsRNA. For all tested, the UVGI dose for 99% inactivation was 2 times higher than that for 90% inactivation, and the ratio of surface to airborne UVGI dose ranged from 3.9 to 7.6. Airborne and surface viruses with single-stranded nucleic acid were more susceptible to UV inactivation than were those with double-stranded ones. For all tested viruses at the same inactivation, the UVGI dose at 85% RH was higher than that at 55% RH, possibly because water sorption onto a virus surface provides protection against UV-induced RNA damage at higher RH. In summary, UVGI was an effective method for virus inactivation.application/pdf303360 bytesapplication/pdfzh-TW國立臺灣大學公共衛生學院環境衛生研究所生物氣膠病毒氣膠噬菌體紫外線bioaerosolsvirus aerosolbacteriophageUVGI[SDGs]SDG3reporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/4888/1/932621Z002003.pdf