National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: Emergence of serotype 19A with high invasive potential

Hsieh Y.-C.Lin P.-Y.Chiu C.-H.Huang Y.-C.Chang K.-Y.Liao C.-H.Chiu N.-C.Chuang Y.-C.Chen P.-Y.SHAN-CHWEN CHANGLiu J.-W.Yen M.-Y.Wang J.-H.Liu C.-Y.Lin T.-Y.2020-12-302020-12-3020090264-410Xhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-68549095936&doi=10.1016%2fj.vaccine.2009.06.091&partnerID=40&md5=aff676d9b89fa90c8ada4097388a1134https://scholars.lib.ntu.edu.tw/handle/123456789/536314We conducted an active, population-based laboratory surveillance study to evaluate the epidemiologic features of invasive pneumococcal disease (IPD) in Taiwan. Concurrently, nasopharyngeal colonization of Streptococcus pneumoniae was evaluated among 1128 healthy children aged ?5 years. The overall incidence was highest among children aged 2-4 years (15.6/100,000). Serotype 19A, which had never been reported in Taiwan previously, caused a substantial fraction of the invasive diseases (OR, 9.6; 95% CI, 3.1-29.4) among children aged 2-4 years. Comparing serotype distributions of the isolates from nasopharyngeal colonization among children aged ?5 years, serotypes 14 (OR, 17.3; 95% CI, 5.2-57.9) and 19A (OR, 14.9; 95% CI, 1.9-117) had the highest invasive potential. The study found that serotype 19A expanded in Taiwan, a country with a low 7-valent conjugate pneumococcal vaccine coverage. The 7-valent conjugate pneumococcal vaccines covered 73% of cases in children aged between 2 and 4 years, and 64.7% of cases in children aged <2 years. Among patients aged ?65 years, the 23-valent pneumococcal polysaccharide vaccine covered 70.4% of cases. In the future, a broader pneumococcal vaccine is needed. ? 2009.Invasive pneumococcal diseases; Invasive potential; Serotype 19A[SDGs]SDG3Pneumococcus vaccine; adolescent; adult; aged; article; bacterial colonization; child; female; health survey; human; major clinical study; male; pneumococcal infection; priority journal; serotype; Streptococcus pneumoniae; Taiwan; Adolescent; Adult; Aged; Child; Child, Preschool; Drug Resistance, Bacterial; Humans; Incidence; Infant; Middle Aged; Pneumococcal Infections; Pneumococcal Vaccines; Population Surveillance; Prospective Studies; Serotyping; Streptococcus pneumoniae; Taiwan; Vaccines, Conjugate; Young AdultNational survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: Emergence of serotype 19A with high invasive potentialjournal article10.1016/j.vaccine.2009.06.09119615960