NP-59 Adrenal Scintigraphy as an Imaging Biomarker to Predict KCNJ5 Mutation in Primary Aldosteronism Patients

CHING-CHU LURUOH-FANG YENPeng, Kang-YungKang-YungPengJEI-YIE HUANGKWAN-DUN WUSHIH-CHIEH CHUEHWAN-YU LIN2021-08-022021-08-0220211664-2392https://scholars.lib.ntu.edu.tw/handle/123456789/575665Somatic KCNJ5 mutation occurs in half of unilateral primary aldosteronism (PA) and is associated with more severe phenotype. Mutation status can only be identified by tissue sample from adrenalectomy. NP-59 adrenal scintigraphy is a noninvasive functional study for disease activity assessment. This study aimed to evaluate the predictive value of NP-59 adrenal scintigraphy in somatic KCNJ5 mutation among PA patients who received adrenalectomy.enKCNJ5; NP-59 adrenal scintigraphy; mutation prediction; primary aldosteronism; semiquantification[SDGs]SDG3dexamethasone; macrolide; adrenal scintiscanning; adrenalectomy; adult; Article; computer assisted tomography; dexamethasone suppression test; diagnostic test accuracy study; disease activity; DNA sequencing; female; gene mutation; human; kcnj5 gene; major clinical study; male; phenotype; primary hyperaldosteronism; retrospective study; sensitivity and specificity; single photon emission computed tomographyNP-59 Adrenal Scintigraphy as an Imaging Biomarker to Predict KCNJ5 Mutation in Primary Aldosteronism Patientsjournal article10.3389/fendo.2021.644927339952772-s2.0-85105907171https://scholars.lib.ntu.edu.tw/handle/123456789/571116