Plumbagin induces the apoptosis of drug-resistant oral cancer in vitro and in vivo through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction

Lin, Chien-LiangChien-LiangLinYu, Chung-IChung-IYuTZONG-HUEI LEEChuang, Jimmy Ming-JungJimmy Ming-JungChuangHan, Kuang-FenKuang-FenHanLin, Chang-ShenChang-ShenLinHuang, Wan-PingWan-PingHuangChen, Jeff Yi-FuJeff Yi-FuChenChen, Chung-YiChung-YiChenLin, Mei-YingMei-YingLinLee, Chien-HsingChien-HsingLee2023-02-182023-02-182023-03-0109447113https://scholars.lib.ntu.edu.tw/handle/123456789/628397Oral cancer is one of the leading causes of cancer-related deaths worldwide. Chemotherapy is widely used in the treatment of oral cancer, but its clinical efficacy is limited by drug resistance. Hence, novel compounds capable of overcoming drug-resistance are urgently needed.enDrug-resistant oral cancer; Endoplasmic reticulum stress; Mitochondrial dysfunction; Plumbagin; Reactive oxygen species[SDGs]SDG3Plumbagin induces the apoptosis of drug-resistant oral cancer in vitro and in vivo through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunctionjournal article10.1016/j.phymed.2023.154655366898582-s2.0-85147458093https://api.elsevier.com/content/abstract/scopus_id/85147458093