邵耀華Shau, Yio-Wha臺灣大學:應用力學研究所游明諫Yu, Ming-ChienMing-ChienYu2010-06-022018-06-292010-06-022018-06-292008U0001-0312200812271200http://ntur.lib.ntu.edu.tw//handle/246246/184737慢性肝病患者的肝組織纖維化程度對於決定患者治療的方式以及評估治療之後的效果是很重要的因子。雖然肝臟穿刺檢驗是評估肝纖維化程度以及肝病成因的黃金標準，但肝穿刺檢驗仍是侵入式的檢驗方法且伴隨有術後併發症的風險、患者的不舒適以及較高的成本等缺點。此外肝穿刺檢驗會因為不合適的組織取樣而會導致假陰性的診斷結果，況且早期肝臟纖維化在穿刺檢查仍有很大的不確定性。因此發展一套簡單、可靠且具有非侵入性的方式來評估患者肝纖維化程度在臨床上是有其必要性。超音波是非常好的軟組織檢測工具，尤其是深部的肝臟。不過超音波影像易受到的干擾與訊號衰減等影響。本研究提出一個基於經驗模態分解法的紋理分析演算法用來從超音波影像中區分患者有無肝組織硬化。16位肝硬化的患者與10位無肝硬化的受試者被用來評估所該演算法的效能。結果顯示第三層經驗模態影像的Normalized Sum Entropy在診斷有無肝硬化上有顯著的統計差異 (p value < 0.0001, AUC = 0.774~0.854)The liver fibrosis stage in patients with viral or non-viral chronic hepatitis is a pivotal factor regarding both the therapeutic options and for predicting the prognosis. Although percutaneous liver biopsy is the gold standard for diagnosing the liver fibrosis stage and predicting the outcome of the diseases, it is still an invasive procedure and associated with a risk of complications, patient discomfort and a high cost. In addition, liver biopsy examinations may lead to false negative results due to inadequate liver tissue sampling. More over, early hepatic fibrosis always exist problems. Therefore, there is an increasing need to develop a simple, reliable and non-invasive method in order to assess the liver fibrosis stage.Ultrasonography is a suitable tool for soft tissue, especially in deeper liver. However, the ultrasonography is often mixed with unwanted reflection and ambiguous attenuation. In this study, We present a texture analysis algorithm based on empirical mode decomposition for differential diagnosis of cirrhotic and noncirrhotic livers from ultrasonography. Patients with cirrhotic liver (n=16) and subjects with noncirrhotic livers (n=10) were studied. Normalized sum entropy of 3rd intrinsic mode image is statistical significant (p<0.0001, Az = 0.774~0.854) in differentiating the noncirrhotic liver and the cirrhotic liver.中文摘要..............................................I文摘要.............................................II文目..............................................III目錄................................................V目錄.............................................VIII一章 序論..........................................1 1-1 前言...........................................1 1-2 研究動機與目的.................................2 1-3 文獻回顧.......................................6二章 研究原理.....................................11 2-1 超音波成像原理................................11 2-2 肝臟生理學....................................13 2-3 經驗模態分解..................................17 2-4 灰階共同發生矩陣..............................23三章 實驗流程與結果...............................31 3-1 受試者資料....................................31 3-2 ROI選取原則...................................32 3-3 紋理特徵擷取..................................33 3-4 實驗結果......................................34 3-5 結果討論......................................47四章 結論.........................................49考文獻.............................................52application/pdf2940372 bytesapplication/pdfen-US肝硬化超音波影像經驗模態分解cirrhosisultrasonographyempirical mode decomposition[SDGs]SDG3thesishttp://ntur.lib.ntu.edu.tw/bitstream/246246/184737/1/ntu-97-R95543018-1.pdf