Lee, Shu-PingShu-PingLeeYang, Shyh-ChyunShyh-ChyunYangCheng, Yen-ShihYen-ShihChengLien, Wan-JungWan-JungLienLEAN-TEIK HUANG2018-09-102018-09-102010-07https://www.scopus.com/pages/publications/77956910478?inwardhttp://scholars.lib.ntu.edu.tw/handle/123456789/356836Tocotrienols, a group of important phytonutrients of palm oil, have been shown to possess antioxidant, anticancer, neuroprotectory, and anti-inflammatory activities. In this study, our objective was to examine the protective effects of tocotrienol-rich fraction (TRF) from palm oil on chronic carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Animals were subjected to vehicle only (control), CCl4 only, CCl4 + 100 mg/kg silymarin (silymarin), CCl4 + 25 mg/kg TRF (TRF-25) and CCl4 + 50 mg/kg TRF (TRF-50) treatments for a period of 8 wks. Results showed that daily oral administration of TRF-25, TRF-50, and silymarin prevented the elevation of serum glutamate oxalate transaminase (sGOT) and glutamate pyruvate transaminase (sGPT), liver thiobarbituric acid reactive substances (TBARS), triglycerides and total cholesterol levels, as well as enhancing the liver catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) levels in rats with hepatotoxicity. At 50 mg/kg, the hepatoprotection of TRF was as good as or better than silymarin (100 mg/kg) in normalization of oxidative stress parameters in liver injury rats. These results suggest that TRF exerts effective protection against chronic CCl4-induced hepatic injury in rats, and its mechanism of action could be related to reducing oxidative stress in the liver tissue.Carbon tetrachlorideHepatotoxicityOxidative stressPalm oilTocotrienol-rich fractionjournal article10.1002/ejlt.2009001752-s2.0-77956910478