Mahajan, AnubhaAnubhaMahajanGo, Min JinMin JinGoZhang, WeihuaWeihuaZhangBelow, Jennifer EJennifer EBelowGaulton, Kyle JKyle JGaultonFerreira, TeresaTeresaFerreiraHorikoshi, MomokoMomokoHorikoshiJohnson, Andrew DAndrew DJohnsonNg, Maggie C YMaggie C YNgProkopenko, IngaIngaProkopenkoSaleheen, DanishDanishSaleheenWang, XuXuWangZeggini, EleftheriaEleftheriaZegginiAbecasis, Goncalo RGoncalo RAbecasisAdair, Linda SLinda SAdairAlmgren, PeterPeterAlmgrenAtalay, MustafaMustafaAtalayAung, TinTinAungBaldassarre, DamianoDamianoBaldassarreBalkau, BeverleyBeverleyBalkauBao, YuqianYuqianBaoBarnett, Anthony HAnthony HBarnettBarroso, InesInesBarrosoBasit, AbdulAbdulBasitBeen, Latonya FLatonya FBeenBeilby, JohnJohnBeilbyBell, Graeme IGraeme IBellBenediktsson, RafnRafnBenediktssonBergman, Richard NRichard NBergmanBoehm, Bernhard OBernhard OBoehmBoerwinkle, EricEricBoerwinkleBonnycastle, Lori LLori LBonnycastleBurtt, NoëlNoëlBurttCai, QiuyinQiuyinCaiCampbell, HarryHarryCampbellCarey, JasonJasonCareyCauchi, StephaneStephaneCauchiCaulfield, MarkMarkCaulfieldChan, Juliana C NJuliana C NChanChang, Li-ChingLi-ChingChangTIEN-JYUN CHANGYI-CHENG CHANGCharpentier, GuillaumeGuillaumeCharpentierChen, Chien-HsiunChien-HsiunChenChen, HanHanChenChen, Yuan-TsongYuan-TsongChenChia, Kee-SengKee-SengChiaChidambaram, ManickamManickamChidambaramChines, Peter SPeter SChinesCho, Nam HNam HChoCho, Young MinYoung MinChoLEE-MING CHUANGCollins, Francis SFrancis SCollinsCornelis, Marylin CMarylin CCornelisCouper, David JDavid JCouperCrenshaw, Andrew TAndrew TCrenshawvan Dam, Rob MRob Mvan DamDanesh, JohnJohnDaneshDas, DebashishDebashishDasde Faire, UlfUlfde FaireDedoussis, GeorgeGeorgeDedoussisDeloukas, PanosPanosDeloukasDimas, Antigone SAntigone SDimasDina, ChristianChristianDinaDoney, Alex SAlex SDoneyDonnelly, Peter JPeter JDonnellyDorkhan, MozhganMozhganDorkhanvan Duijn, CorneliaCorneliavan DuijnDupuis, JoséeJoséeDupuisEdkins, SarahSarahEdkinsElliott, PaulPaulElliottEmilsson, ValurValurEmilssonErbel, RaimundRaimundErbelEriksson, Johan GJohan GErikssonEscobedo, JorgeJorgeEscobedoEsko, TonuTonuEskoEury, ElodieElodieEuryFlorez, Jose CJose CFlorezFontanillas, PierrePierreFontanillasForouhi, Nita GNita GForouhiForsen, TomTomForsenFox, CarolineCarolineFoxFraser, Ross MRoss MFraserFrayling, Timothy MTimothy MFraylingFroguel, PhilippePhilippeFroguelFrossard, PhilippePhilippeFrossardGao, YutangYutangGaoGertow, KarlKarlGertowGieger, ChristianChristianGiegerGigante, BrunaBrunaGiganteGrallert, HaraldHaraldGrallertGrant, George BGeorge BGrantGrrop, Leif CLeif CGrropGroves, Chrisropher JChrisropher JGrovesGrundberg, ElinElinGrundbergGuiducci, CandaceCandaceGuiducciHamsten, AndersAndersHamstenHan, Bok-GheeBok-GheeHanHara, KazuoKazuoHaraHassanali, NeelamNeelamHassanaliHattersley, Andrew TAndrew THattersleyHayward, CarolineCarolineHaywardHedman, Asa KAsa KHedmanHerder, ChristianChristianHerderHofman, AlbertAlbertHofmanHolmen, Oddgeir LOddgeir LHolmenHovingh, KeesKeesHovinghHreidarsson, Astradur BAstradur BHreidarssonHu, ChengChengHuHu, Frank BFrank BHuHui, JennieJennieHuiHumphries, Steve ESteve EHumphriesHunt, Sarah ESarah EHuntHunter, David JDavid JHunterHveem, KristianKristianHveemHydrie, Zafar IZafar IHydrieIkegami, HiroshiHiroshiIkegamiIllig, ThomasThomasIlligIngelsson, ErikErikIngelssonIslam, MuhammedMuhammedIslamIsomaa, BoBoIsomaaJackson, Anne UAnne UJacksonJafar, TazeenTazeenJafarJames, AlanAlanJamesJia, WeipingWeipingJiaJöckel, Karl-HeinzKarl-HeinzJöckelJonsson, AnnaAnnaJonssonJowett, Jeremy B MJeremy B MJowettKadowaki, TakashiTakashiKadowakiKang, Hyun MinHyun MinKangKanoni, StavroulaStavroulaKanoniKao, Wen Hong LWen Hong LKaoKathiresan, SekarSekarKathiresanKato, NorihiroNorihiroKatoKatulanda, PrasadPrasadKatulandaKeinanen-Kiukaanniemi, Kirkka MKirkka MKeinanen-KiukaanniemiKelly, Ann MAnn MKellyKhan, HassanHassanKhanKhaw, Kay-TeeKay-TeeKhawKhor, Chiea-ChuenChiea-ChuenKhorKim, Hyung-LaeHyung-LaeKimKim, SangsooSangsooKimKim, Young JinYoung JinKimKinnunen, LeenaLeenaKinnunenKlopp, NormanNormanKloppKong, AugustineAugustineKongKorpi-Hyövälti, EevaEevaKorpi-HyövältiKowlessur, SudhirSudhirKowlessurKraft, PeterPeterKraftKravic, JasminaJasminaKravicKristensen, Malene MMalene MKristensenKrithika, SSKrithikaKumar, AshishAshishKumarKumate, JesusJesusKumateKuusisto, JohannaJohannaKuusistoKwak, Soo HeonSoo HeonKwakLaakso, MarkkuMarkkuLaaksoLagou, VasilikiVasilikiLagouLakka, Timo ATimo ALakkaLangenberg, ClaudiaClaudiaLangenbergLangford, CordeliaCordeliaLangfordLawrence, RobertRobertLawrenceLeander, KarinKarinLeanderLee, Jen-MaiJen-MaiLeeLee, Nanette RNanette RLeeLi, ManManLiLi, XinzhongXinzhongLiLi, YunYunLiLiang, JunbinJunbinLiangLiju, SamuelSamuelLijuLim, Wei-YenWei-YenLimLind, LarsLarsLindLindgren, Cecilia MCecilia MLindgrenLindholm, EeroEeroLindholmLiu, Ching-TiChing-TiLiuLiu, Jian JunJian JunLiuLobbens, StéphaneStéphaneLobbensLong, JirongJirongLongLoos, Ruth J FRuth J FLoosLu, WeiWeiLuLuan, Jian'anJian'anLuanLyssenko, ValeriyaValeriyaLyssenkoMa, Ronald C WRonald C WMaMaeda, ShiroShiroMaedaMägi, ReedikReedikMägiMännisto, SatuSatuMännistoMatthews, David RDavid RMatthewsMeigs, James BJames BMeigsMelander, OlleOlleMelanderMetspalu, AndresAndresMetspaluMeyer, JuliaJuliaMeyerMirza, GhazalaGhazalaMirzaMihailov, EvelinEvelinMihailovMoebus, SusanneSusanneMoebusMohan, ViswanathanViswanathanMohanMohlke, Karen LKaren LMohlkeMorris, Andrew DAndrew DMorrisMühleisen, Thomas WThomas WMühleisenMüller-Nurasyid, MartinaMartinaMüller-NurasyidMusk, BillBillMuskNakamura, JiroJiroNakamuraNakashima, EitaroEitaroNakashimaNavarro, PauPauNavarroNg, Peng-KeatPeng-KeatNgNica, Alexandra CAlexandra CNicaNilsson, Peter MPeter MNilssonNjølstad, IngerIngerNjølstadNöthen, Markus MMarkus MNöthenOhnaka, KeizoKeizoOhnakaOng, Twee HeeTwee HeeOngOwen, Katharine RKatharine ROwenPalmer, Colin N AColin N APalmerPankow, James SJames SPankowPark, Kyong SooKyong SooParkParkin, MelissaMelissaParkinPechlivanis, SonaliSonaliPechlivanisPedersen, Nancy LNancy LPedersenPeltonen, LeenaLeenaPeltonenPerry, John R BJohn R BPerryPeters, AnnetteAnnettePetersPinidiyapathirage, Janini MJanini MPinidiyapathiragePlatou, Carl GCarl GPlatouPotter, SimonSimonPotterPrice, Jackie FJackie FPriceQi, LuLuQiRadha, VenkatesanVenkatesanRadhaRallidis, LoukianosLoukianosRallidisRasheed, AsifAsifRasheedRathman, WolfgangWolfgangRathmanRauramaa, RainerRainerRauramaaRaychaudhuri, SoumyaSoumyaRaychaudhuriRayner, N WilliamN WilliamRaynerRees, Simon DSimon DReesRehnberg, EmilEmilRehnbergRipatti, SamuliSamuliRipattiRobertson, NeilNeilRobertsonRoden, MichaelMichaelRodenRossin, Elizabeth JElizabeth JRossinRudan, IgorIgorRudanRybin, DenisDenisRybinSaaristo, Timo ETimo ESaaristoSalomaa, VeikkoVeikkoSalomaaSaltevo, JuhaJuhaSaltevoSamuel, MariaMariaSamuelSanghera, Dharambir KDharambir KSangheraSaramies, JoukoJoukoSaramiesScott, JamesJamesScottScott, Laura JLaura JScottScott, Robert ARobert AScottSegrè, Ayellet VAyellet VSegrèSehmi, JobanJobanSehmiSennblad, BengtBengtSennbladShah, NabiNabiShahShah, SoniaSoniaShahShera, A SamadA SamadSheraShu, Xiao OuXiao OuShuShuldiner, Alan RAlan RShuldinerSigurđsson, GunnarGunnarSigurđssonSijbrands, EricEricSijbrandsSilveira, AngelaAngelaSilveiraSim, XuelingXuelingSimSivapalaratnam, SutheshSutheshSivapalaratnamSmall, Kerrin SKerrin SSmallSo, Wing YeeWing YeeSoStančáková, AlenaAlenaStančákováStefansson, KariKariStefanssonSteinbach, GeraldGeraldSteinbachSteinthorsdottir, ValgerdurValgerdurSteinthorsdottirStirrups, KathleenKathleenStirrupsStrawbridge, Rona JRona JStrawbridgeStringham, Heather MHeather MStringhamSun, QiQiSunSuo, ChenChenSuoSyvänen, Ann-ChristineAnn-ChristineSyvänenTakayanagi, RyoichiRyoichiTakayanagiTakeuchi, FumihikoFumihikoTakeuchiTay, Wan TingWan TingTayTeslovich, Tanya MTanya MTeslovichThorand, BarbaraBarbaraThorandThorleifsson, GudmarGudmarThorleifssonThorsteinsdottir, UnnurUnnurThorsteinsdottirTikkanen, EmmiEmmiTikkanenTrakalo, JosephJosephTrakaloTremoli, ElenaElenaTremoliTrip, Mieke DMieke DTripTsai, Fuu JenFuu JenTsaiTuomi, TiinamaijaTiinamaijaTuomiTuomilehto, JaakkoJaakkoTuomilehtoUitterlinden, Andre GAndre GUitterlindenValladares-Salgado, AdanAdanValladares-SalgadoVedantam, SailajaSailajaVedantamVeglia, FabrizioFabrizioVegliaVoight, Benjamin FBenjamin FVoightWang, CongrongCongrongWangWareham, Nicholas JNicholas JWarehamWennauer, RomanRomanWennauerWickremasinghe, Ananda RAnanda RWickremasingheWilsgaard, TomTomWilsgaardWilson, James FJames FWilsonWiltshire, StevenStevenWiltshireWinckler, WendyWendyWincklerWong, Tien YinTien YinWongWood, Andrew RAndrew RWoodWu, Jer-YuarnJer-YuarnWuWu, YingYingWuYamamoto, KenKenYamamotoYamauchi, ToshimasaToshimasaYamauchiYang, MingyuMingyuYangYengo, LoicLoicYengoYokota, MitsuhiroMitsuhiroYokotaYoung, RobinRobinYoungZabaneh, DelilahDelilahZabanehZhang, FanFanZhangZhang, RongRongZhangZheng, WeiWeiZhengZimmet, Paul ZPaul ZZimmetAltshuler, DavidDavidAltshulerBowden, Donald WDonald WBowdenCho, Yoon ShinYoon ShinChoCox, Nancy JNancy JCoxCruz, MiguelMiguelCruzHanis, Craig LCraig LHanisKooner, JaspalJaspalKoonerLee, Jong-YoungJong-YoungLeeSeielstad, MarkMarkSeielstadTeo, Yik YingYik YingTeoBoehnke, MichaelMichaelBoehnkeParra, Esteban JEsteban JParraChambers, Jonh CJonh CChambersTai, E ShyongE ShyongTaiMcCarthy, Mark IMark IMcCarthyMorris, Andrew PAndrew PMorris2023-02-082023-02-082014-031061-4036https://scholars.lib.ntu.edu.tw/handle/123456789/627702To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.enASSOCIATION ANALYSES; GLUCOSE-HOMEOSTASIS; LOCI; VARIANTS; INDIVIDUALS; CHROMATIN; IDENTIFY[SDGs]SDG3journal article10.1038/ng.2897245094802-s2.0-84895868553WOS:000332036700007https://api.elsevier.com/content/abstract/scopus_id/84895868553