CHE-YU LINYI-CHUNG SHULan-Rong ChenWEI-TING WUKE-VIN CHANG2025-06-172025-06-172025-06https://www.scopus.com/record/display.uri?eid=2-s2.0-105002217421&origin=resultslisthttps://scholars.lib.ntu.edu.tw/handle/123456789/730135Tendon and ligament injuries remain a significant challenge for clinicians, despite considerable efforts to develop effective treatment methods. This study reviewed in vivo human studies investigating the use of platelet gel, a blood-derived biomaterial that enhances tissue healing, for treating tendon and ligament injuries. Only eight relevant articles were identified, highlighting the limited number of available studies on this topic. Of these eight articles, three reported significant positive treatment effects, two found no significant benefit, and three observed varying degrees of improvement, although not always statistically significant. Overall, six of the eight studies indicated positive effects of platelet gel based on clinical and radiographic outcomes, suggesting its potential as a promising treatment. Further clinical studies are required to confirm its efficacy and establish its role in tendon and ligament healing.BiomaterialPlatelet-rich plasmaRegenerative medicineTearTendinopathy[SDGs]SDG3review10.1016/j.reth.2025.03.022