Wang, I.-S.I.-S.WangJEN-KUANG LEELin, H.-H.H.-H.LinSun, Y.-H.Y.-H.SunChen, G.-Y.G.-Y.ChenCHIH-TING LIN2022-03-072022-03-072015#VALUE!https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955517122&doi=10.1109%2fTRANSDUCERS.2015.7181260&partnerID=40&md5=40ede5a806c9fde4f3184fe74d03a21ahttps://scholars.lib.ntu.edu.tw/handle/123456789/596601This paper reports an integrated poly-silicon sub-micron wire biosensor for multiple biomarker detections in clinical samples. It is fabricated by a commercialized 0.35μm CMOS process node. For the first time, an integrated CMOS biosensor chip is experimentally validated in human whole blood and plasma. In this work, a series of anemia/diabetes biomarkers, such as low-density lipoprotein (LDL), hemoglobin (Hb), glycated hemoglobin (HbA1c), and ferritin are examined by the developed CMOS poly-silicon biosensors. The experimental results successfully indicate differences of biomarker concentrations between sick and healthy people. As a consequence, this work demonstrates a potential of CMOS applications in clinical biomarker detections for point-of-care technology. ? 2015 IEEE.[SDGs]SDG3Actuators; Biosensors; CMOS integrated circuits; Hemoglobin; Microsystems; Polysilicon; Silicon; Solid-state sensors; Transducers; Wire; Clinical biomarkers; Clinical samples; CMOS biosensors; Field effects; Glycated hemoglobin (HbA1c); Low density lipoproteins; Multiple biomarkers; Sub-micron wires; Biomarkersconference paper10.1109/TRANSDUCERS.2015.71812602-s2.0-84955517122