國立臺灣大學電機工程學系暨研究所鍾孝文2006-07-252018-07-062006-07-252018-07-062002-07-31http://ntur.lib.ntu.edu.tw//handle/246246/7859本計畫之目的在於發展一系列的影像 分析技術，用於動態臨床微灌流磁振造 影，並將給予血管擴張劑 acetazolamide 前 後之大腦血流 (cerebral blood flow) 差異 予以絕對定量，以利計算暫時缺血性中風 (transient ischemic attack) 病患之腦血容積 (cerebrovascular reserve capacity)。暫時缺血 性中風定義為中風症狀於發生後二十四小 時內消除之病患。在計畫一年期之內，我 們以奇異值分解法完成大腦血流的定量 化，並且發現如今國際間廣泛使用的演算 方式具有明顯的誤差，而此誤差與組織平 均穿流時間 (mean transit time) 相關。由於 平均穿流時間在暫時缺血性中風病患大腦 中與正常組織明顯不同，因而計算誤差將 導致無法忽略的錯誤。我們在計畫中進一 步提出改善方案，將誤差由 +/-25% 減低 至約 5%。The purpose of this one-year project is to develop a series of image analysis methods on clinical dynamic susceptibility-contrast perfusion-weighted magnetic resonance (MR) imaging to quantify the cerebrovascular reserve capacity (CRC) during vasodilating challenge task with acetazolamide (diamox). The specific clinical target of the project is transient ischemic attack (TIA), that is, patients with symptoms of ischemic stroke but recovered within 24 hours. Within one fiscal year we have implemented the deconvolution method based on the singular value decomposition to derive cerebral blood flow (CBF), from which the cerebrovascular reserve capacity can be directly computed. The CBF analysis algorithm widely used in most international medical center has been shown to exhibit significant prediction errors dependent on tissue mean-transit-time (MTT), which can vary substantially in pathological conditions encountered in TIA patients. We further proposed a method to remedy this algorithm drawback to reduce the CBF estimation error from the original +/-25% to 5%.application/pdf158717 bytesapplication/pdfzh-TW國立臺灣大學電機工程學系暨研究所perfusionmagnetic resonancetransient ischemic attackabsolute quantification of cerebral blood flowsingular value decompositioncerebral blood reserve capacity微灌流磁振暫時性腦缺血絕對定量腦血流奇異值分解腦血容reporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/7859/1/902213E002102.pdf