�Y�s�S2018-07-122018-07-122003http://ntur.lib.ntu.edu.tw//handle/246246/22628骨質疏鬆症是廿一世紀人類因人口老化所將面臨的重大問題，尤其是婦女在停經後快速的骨質流失更是造成低骨密度，乃至骨質疏鬆、骨折的主要因素。據統計在美國一年有150 萬例因骨質疏鬆導致的骨折，台灣在進入本世紀不久將會與歐美國家一樣走上人口高度老化的程度。 台灣地區目前雖已有學者提出的骨密度平均值表及標準差，但皆為橫斷面的研究，且皆沒有深入探討其相關的危險或保護因子。為探討相關危險及保護因子，並補正橫斷面研究可能的缺失，本研究計畫乃是以社區為範圍，為期三年的世代追蹤研究。以下報告研究進行的方式與第一年的成果。我們以台北市為主，收錄已停經的婦女，予以測量及調查其基本資料（年齡、身高、體重、腰臀比…等）及生活型態(有無抽煙、喝酒、日常運動量多寡…等)，並詳細詢問其月經生育史（初經及停經年齡、懷孕及生產次數、有無哺餵母乳…等）及相關疾病家族史。每位受檢婦女皆接受DEXA（Dual Energy X-ray Absorptiometry）測量腰椎及左大腿股骨頭關節的骨質密度（BMD - bone mineral density）及全身脂肪分布，並驗尿抽血檢驗骨代謝指標Dpd / Cre（Deoxypyridinoline / Creatinine）。這第一年的資 料主要是做為以後第二年及第三年世代追蹤的基準值。 從2002 年9 月起截至2003 年7 月底共完成280 位停經後婦女的骨密度及其相關資料之調查。其骨密度及基本資料結果如後面附錄所示。將待第二年及第三年全部受測人數完成滿二年的追蹤後，再予以統計分析。由於原先研究設計尚稱周詳，故第一年研究之進行尚無碰到重大困難。唯一的問題是因2003 年上半年SARS 的肆虐，被抽中測量的社區民眾不敢到醫療院所，導致收案個數較原先計劃者為少。Osteoporosis is a major public health concern of the 21st century due to the rapidly increasing elderly population worldwide. Women especially will lose bone rapidly after the menopause, which can lead to osteopenia initially, with worsening to osteoporosis and an increased propensity to fracture. Statistics from the USA show approximately 1.5 million fractures occurring each year as a consequence of osteoporosis. The steep increase in the elderly population of Taiwan in recent decades, similar to Western developed nations, will further emphasize the urgency of preventative strategy against osteoporosis. Although there have been studies on the bone mineral density (BMD) of Taiwanese women, these studies, however, were mainly cross-sectional in nature. In order to investigate reproductive and lifestyle risk factors or protective factors for bone loss in the postmenopausal years and avoid the shortcomings of a cross-sectional study design, this longitudinal community-based cohort study with a 2-year follow-up were carried out. We include 280 postmenopausal women as study subjects in the first year. Using a questionnaire, baseline characteristics (age, years of education, etc.), lifestyle characteristics (ever smoked, drink alcohol, physical activity level, etc.), reproductive history (age at menarche and menopause, parity and number of livebirths, breastfeeding, etc.), as well as pertinent medical and family history were recorded. Anthropometric measurements were taken of each subject (height, weight, BMI, waist-hip ratio (WHR), etc.). Every subject received dual energy X-ray absorptiometry (DEXA) measurements of BMD ( bone mineral density) for the lumbar spine and left hip and total body fat distribution. Urine sampling and blood drawing were done to test the bone turnover marker deoxypyridinoline (Dpd). The data collected during the first year here will be used as baseline to compare with any weight, height, lifestyle and BMD changes 1 and 2 years later. Part of these original data were shown in appendix. The only problem we encounter during the first - year study is SARS episode, which hindered subjects from receiving DEXA exam at hospital. Hence the subject number enrolled is less than planned.application/pdf165151 bytesapplication/pdfzh-TW國立臺灣大學醫學院一般醫學科骨密度停經世代追蹤研究危險因子bone mineral density (BMD)menopausecohort studyrisk factor[SDGs]SDG3journal articlehttp://ntur.lib.ntu.edu.tw/bitstream/246246/22628/1/912314B002387.pdf