Lee, Tung-LinTung-LinLeeTSEN-FANG TSAI2022-09-202022-09-202022-021023-3830https://scholars.lib.ntu.edu.tw/handle/123456789/621250Psoriasis is an inflammatory disease characterized by skin thickening with silvery white desquamation due to dysregulated inflammatory pathways and elevated levels of inflammatory cytokines. Biologic agents targeting these inflammatory cytokines have brought about significant improvement in clearing psoriatic lesions in patients with moderate-to-severe psoriasis. Moreover, biologics exert both beneficial and detrimental effects on comorbidities in psoriasis, which include increased risk of cardiovascular events, metabolic syndrome, among other conditions. However, non-immune functions of cytokines targeted by biologics, and, hence, the potential risks and benefits of biologics for psoriasis to different organs/systems and comorbidities, have not been well elucidated.enBiologic agents; Inflammatory cytokines; Psoriasis; Psoriasis-related comorbidities[SDGs]SDG2[SDGs]SDG3review10.1007/s00011-021-01528-0349811302-s2.0-85122186332WOS:000737821100001https://api.elsevier.com/content/abstract/scopus_id/85122186332