CHIH-CHUNG YANGYEAN-WOEI KIANGTseng, H.-Y.H.-Y.TsengChen, W.-F.W.-F.ChenChu, C.-K.C.-K.ChuChang, W.-Y.W.-Y.ChangKuo, Y.Y.KuoKiang, Y.-W.Y.-W.KiangCHIH-CHUNG YANGYEAN-WOEI KIANG2018-09-102018-09-102013http://www.scopus.com/inward/record.url?eid=2-s2.0-84872952744&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/378426The on-substrate fabrication of a bio-conjugated Au nanoring (NRI) solution with the localized surface plasmon (LSP) resonance wavelength in the 1200-1300 nm range is demonstrated. Also, the effects of photothermal therapy through LSP resonance-induced absorption enhancement are illustrated by applying the bio-conjugated Au NRIs to human liver cancer cells and illuminating the cells with a laser of 1315 nm in wavelength. The Au NRI fabrication is based on the techniques of nano-imprint lithography and metal secondary sputtering. The procedure for on-substrate surface modification of Au NRIs leads to a high production yield of bio-conjugated NRIs. The threshold levels of the local laser intensity for injuring cancer cells based on the LSP resonances of Au NRIs of two different samples are determined. ? 2013 IOP Publishing Ltd.[SDGs]SDG3Absorption enhancement; Au nanoring; Cancer cells; Human liver cancer cells; Laser intensities; Localized surface plasmon; Photothermal therapy; Production yield; Resonance wavelengths; Threshold levels; Cells; Lasers; Nanoimprint lithography; Nanorings; Nanostructured materials; Resonance; Fabrication; gold; nanomaterial; article; cell strain HepG2; chemistry; human; hyperthermic therapy; liver; liver tumor; methodology; nanotechnology; pathology; phototherapy; solution and solubility; surface plasmon resonance; Gold; Hep G2 Cells; Humans; Hyperthermia, Induced; Liver; Liver Neoplasms; Nanostructures; Nanotechnology; Phototherapy; Solutions; Surface Plasmon Resonancejournal article10.1088/0957-4484/24/6/0651022-s2.0-84872952744WOS:000313911900002