Luh S.-P.Lee Y.-C.YIH-LEONG CHANGWu H.-D.Kuo S.-H.Chu S.-H.2020-03-072020-03-0719990902-0063https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033405629&doi=10.1034%2fj.1399-0012.1999.130610.x&partnerID=40&md5=68b9c9b0430c3047c3a9a90b0ef7df74https://scholars.lib.ntu.edu.tw/handle/123456789/473961Sauropus androgynus (SA), a vegetable of the Euphorbiaceae family, is a common food source in Malaysia. In Taiwan, over 30 patients have developed progressive respiratory failure after consuming the extract from raw SA leaves as a means of losing weight. Symptoms consistent with a severe obstructive ventilatory defect progressed, despite cessation of SA intake and treatment with bronchodilators, corticosteroids, cytotoxic agents and plasmaphresis. Five patients with end-stage Sauropus androgynus-induced bronchiolitis obliterans (SABO) syndrome underwent lung transplantation. There was no early mortality. One patient died of post-transplant lymphoproliferative disorder and another patient died of bronchial stenosis with infection, 5 and 3.5 months, respectively, post-transplantation. The remaining 3 patients have been followed from 29 to 34 months, with improved general condition and pulmonary function. Perfusion/ventilation scans revealed that these improvements were exclusively attributed to the functional grafts. We believe that lung transplantation is the only effective modality of treatment for patients with end-stage SABO syndrome.[SDGs]SDG3bronchodilating agent; corticosteroid; cytotoxic agent; adult; article; bronchiolitis; bronchus stenosis; case report; Euphorbia; female; human; infection; lung function; lung transplantation; lymphoproliferative disease; plasmapheresis; priority journal; Adult; Bronchiolitis Obliterans; Female; Humans; Lung Transplantation; Middle Aged; Vegetablesjournal article10.1034/j.1399-0012.1999.130610.x106172402-s2.0-0033405629