Lee T.-M.Charng M.-J.Tseng C.-D.LING-PING LAI2020-12-312020-12-3120161011-6842https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978389179&doi=10.6515%2fACS20150708D&partnerID=40&md5=bebf6a4db2912f38c328fee8e264fa0ehttps://scholars.lib.ntu.edu.tw/handle/123456789/536600Background: Green tea intake has been shown to improve endurance capacity in animal studies, but whether it has a similar effect on humans remains unclear. A randomized, double-blinded, parallel-controlled study was conducted to evaluate the short-term effect of STA-2, a pharmaceutical preparation of green tea polyphenols, in patients with effort-induced angina and documented positive exercise tolerance test. Methods: A total of 79 patients recruited from three medical centers were randomly assigned to receive 2 STA-2 250 mg capsules, each containing 100 mg green tea polyphenols, three times daily, or placebo for six weeks after two consecutive symptom-limited treadmill exercise tests to ascertain the reproducibility of exercise tolerance. Results: There was no difference in total exercise tolerance time frombaseline toWeek 6 between two groups (p = 0.639). There were also no observed improvements in subgroup analyses stratified by age, gender, and BMI categories. However, a significant reduction in low-density lipoprotein levels was shown in patients in the STA-2 group (-8.99 ± 19.18 mg/dL) versus the placebo group (0.57 ± 19.77 mg/dL), p = 0.037, with greater benefits in patients not taking antihyperlipidemic drugs (STA-2: -9.10 ± 19.96 mg/dL vs. placebo: 4.42 ± 15.08 mg/dL, p = 0.037). Conclusions: STA-2 treatment for 6 weeks did not increase exercise time asmeasured on a treadmill. However, this study also indicated that STA-2 treatment could have potential beneficial effects on LDL-cholesterol concentrations. ? 2016, Republic of China Society of Cardiology. All rights reserved.Chronic stable angina; Coronary disease; Green tea polyphenols; Ischemia; Low density lipoprotein (LDL)[SDGs]SDG39,11 epithio 11,12 methanothromboxane A2; C reactive protein; green tea extract; lactate dehydrogenase; low density lipoprotein; placebo; plasminogen; polyphenol derivative; adult; antioxidant activity; Article; body mass; Camellia sinensis; controlled study; double blind procedure; drug efficacy; drug safety; electrocardiography; exercise tolerance; female; high performance liquid chromatography; human; major clinical study; male; middle aged; multicenter study; oxidative stress; randomized controlled trial; stable angina pectoris; tea; thin layer chromatography; treadmill exercisejournal article10.6515/ACS20150708D2-s2.0-84978389179