Lai J.-Y.Wu P.-C.HSI-CHUNG CHENMING-BEEN LEE2021-02-042021-02-04201216383432-s2.0-84865386362https://scholars.lib.ntu.edu.tw/handle/123456789/548550Objective: Neuropsychiatric symptoms may be the main manifestations and very early symptoms of developing autoimmune diseases. Early detection and treatment could reverse psychotic symptoms and restore cognitive function. Case Report: A 24-year-old woman presented with acute psychotic symptoms. Routine physical examinations revealed only mild fever. Due to positive antiphospholipid antibodies, low protein S with elevated d-dimer and brain hypoperfusion, early-phase antiphospholipid syndrome (APS) was suspected. Early immunomodulation treatment led to complete remission of the psychotic symptoms, preservation of cognitive function and prevention of APS progression. Conclusion: Since early detection and treatment can reverse the progression of autoimmune diseases with central nervous system involvement, these should be highlighted when managing high-risk patients. ? 2012 Elsevier Inc.[SDGs]SDG3acetylsalicylic acid; aciclovir; cardiolipin antibody; ceftriaxone; D dimer; hydroxychloroquine; immunoglobulin G antibody; methylprednisolone; olanzapine; phospholipid antibody; prednisolone; protein S; acute psychosis; adult; antiphospholipid syndrome; article; brain hypoperfusion; brain perfusion; case report; clinical feature; cognition; differential diagnosis; drug pulse therapy; early diagnosis; early intervention; female; fever; follow up; human; immunomodulation; infection; low drug dose; neurologic examination; persecutory delusion; physical examination; remission; schizophrenia; serology; single photon emission computer tomography; symptom; Wechsler Intelligence Scalejournal article10.1016/j.genhosppsych.2012.02.00522460000