Chang, Chih-HungChih-HungChangKuo, Tzong-FuTzong-FuKuoLin, Chien-ChengChien-ChengLinChou, Cheng-HungCheng-HungChouChen, Kuang-HoKuang-HoChenLin, Feng-HueiFeng-HueiLinLiu, Hwa-ChangHwa-ChangLiu2009-02-112018-06-292009-02-112018-06-29200601429612http://ntur.lib.ntu.edu.tw//handle/246246/128023http://ntur.lib.ntu.edu.tw/bitstream/246246/128023/1/62.pdfhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-28744449647&doi=10.1016%2fj.biomaterials.2005.10.014&partnerID=40&md5=d557194553bdc05ba2cab5cad85710a0We previously showed that cartilage tissue can be engineered in vitro with porcine chondrocytes and gelatin/chondoitin-6-sulfate/hyaluronan tri-copolymer which mimic natural cartilage matrix for use as a scaffold. In this animal study, 15 miniature pigs were used in a randomized control study to compare tissue engineering with allogenous chondrocytes, autogenous osteochondral (OC) transplantation, and spontaneous repair for OC articular defects. In another study, 6 pigs were used as external controls in which full thickness (FT) and OC defects were either allowed to heal spontaneously or were filled with scaffold alone. After exclusion of cases with infection and secondary arthritis, the best results were obtained with autogenous OC transplantation, except that integration into host cartilage was poor. The results for the tissue engineering-treated group were satisfactory, the repair tissue being hyaline cartilage and/or fibrocartilage. Spontaneous healing and filling with scaffold alone did not result in good repair. With OC defects, the subchondral bone plate was not restored by cartilage tissue engineering. These results show that tri-copolymer can be used in in vivo cartilage tissue engineering for the treatment of FT articular defects.application/pdf874893 bytesapplication/pdfen-USAnimal model; Cartilage tissue engineering; Chondroitin sulfate; Gelatin; Hyaluronan[SDGs]SDG3Copolymers; Tissue; Transplants; Animal model; Cartilage tissue engineering; Gelatin; Hyaluronan; Cartilage; chondroitin; chondroitin sulfate; copolymer; gelatin; hyalin; hyaluronic acid; animal cell; animal experiment; animal model; animal tissue; arthritis; arthropathy; article; autograft; bone plate; bone remodeling; cartilage cell; cell transplantation; controlled study; experimental model; female; instrumentation; male; nonhuman; osteocyte; priority journal; randomization; satisfaction; swine; thickness; time series analysis; tissue engineering; tissue repair; Animals; Cartilage, Articular; Chondrocytes; Chondroitin; Female; Hyaluronic Acid; Knee Joint; Male; Osteochondritis; Regeneration; Sus scrofa; Tissue Engineering; Transplantation, Homologous; Animalia; Suidae; Sus scrofajournal article10.1016/j.biomaterials.2005.10.014162780142-s2.0-28744449647http://ntur.lib.ntu.edu.tw/bitstream/246246/128023/1/62.pdf