Michowitz Y.Milman A.Sarquella-Brugada G.Andorin A.Champagne J.Postema P.G.Casado-Arroyo R.Leshem E.JYH-MING JIMMY JUANGGiustetto C.Tfelt-Hansen J.Wijeyeratne Y.D.Veltmann C.Corrado D.Kim S.-H.Delise P.Maeda S.Gourraud J.-B.Sacher F.Mabo P.Takahashi Y.Kamakura T.Aiba T.Conte G.Hochstadt A.Mizusawa Y.Rahkovich M.Arbelo E.Huang Z.Denjoy I.Napolitano C.Brugada R.Calo L.Priori S.G.Takagi M.Behr E.R.Gaita F.Yan G.-X.Brugada J.Leenhardt A.Wilde A.A.M.Brugada P.Kusano K.F.Hirao K.Nam G.-B.Probst V.Belhassen B.2020-12-282020-12-2820181547-5271https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047178178&doi=10.1016%2fj.hrthm.2018.04.007&partnerID=40&md5=5cd85c6c137f60e6c62579d127169e6chttps://scholars.lib.ntu.edu.tw/handle/123456789/534012Background: The literature on fever-related arrhythmic events (AEs) in Brugada syndrome (BrS) is currently limited to few case reports and small series. Objective: The present study aimed to describe the characteristics of fever-related AE in a large cohort of patients with BrS. Methods: The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter study on 678 patients with BrS with first AE documented at the time of aborted cardiac arrest (n = 426) or after prophylactic implantable cardioverter-defibrillator implantation (n = 252). Results: In 35 of 588 patients (6%) with available information, the AE occurred during a febrile illness. Most of the 35 patients were male (80%), Caucasian (83%), and proband (70%). The mean age at the time of AE was 29 ± 24 years (range 0.3–76 years). Most patients (80%) presented with aborted cardiac arrest and 6 (17%) with arrhythmic storm. Family history of sudden death, history of syncope, and spontaneous type 1 Brugada electrocardiogram were noted in 17%, 40%, and 71% of patients, respectively. Ventricular fibrillation was induced at electrophysiology study in 9 of 19 patients (47%). An SCN5A mutation was found in 14 of 28 patients (50%). The highest proportion of fever-related AE was observed in the pediatric population (age <16 years), with a disproportionally higher event rate in the very young (age 0–5 years) (65%). Males were involved in all age groups and females only in the pediatric and elderly groups. Fever-related AE affected 17 Caucasians aged <24 years, but no Asians aged <24 years. Conclusion: The risk of fever-related AE in BrS markedly varies according to age group, sex, and ethnicity. Taking these factors into account could help the clinical management of patients with BrS with fever. ? 2018 Heart Rhythm SocietyBrugada syndrome; Children; Elderly; Ethnicity; Fever; Sex[SDGs]SDG3sodium channel Nav1.5; adolescent; adult; age distribution; aged; Article; Asian; Brugada syndrome; cardiac patient; cardiovascular risk; Caucasian; child; clinical observation; cohort analysis; comparative study; disease association; ECG abnormality; electrocardiogram; ethnic difference; faintness; family history; female; fever; gene mutation; heart arrest; heart arrhythmia; heart electrophysiology; heart ventricle fibrillation; human; infant; major clinical study; male; newborn; pediatric cardiology; priority journal; retrospective study; sex difference; sex ratio; sudden death; Brugada syndrome; clinical trial; complication; electrocardiography; fever; heart ventricle fibrillation; middle aged; multicenter study; pathophysiology; preschool child; prognosis; questionnaire; young adult; Adolescent; Adult; Aged; Brugada Syndrome; Child; Child, Preschool; Electrocardiography; Female; Fever; Humans; Infant; Infant, Newborn; Male; Middle Aged; Prognosis; Surveys and Questionnaires; Ventricular Fibrillation; Young Adultjournal article10.1016/j.hrthm.2018.04.007296496152-s2.0-85047178178