Su W.-J.Chan T.-C.Chuang P.-H.Liu Y.-L.PING-ING LEELiu M.-T.Chuang J.-H.2021-01-072021-01-0720151201-9712https://www.scopus.com/inward/record.uri?eid=2-s2.0-84918562947&doi=10.1016%2fj.ijid.2014.11.011&partnerID=40&md5=7044dac6fa91bad362ff08d859038169https://scholars.lib.ntu.edu.tw/handle/123456789/539538Objectives: We aimed to estimate the pooled vaccine effectiveness (VE) in children over five winters through data linkage of two existing surveillance systems. Methods: Five test-negative case-control studies were conducted from November to February during the 2004/2005 to 2008/2009 seasons. Sentinel physicians from the Viral Surveillance Network enrolled children aged 6-59 months with influenza-like illness to collect throat swabs. Through linking with a nationwide vaccination registry, we measured the VE with a logistic regression model adjusting for age, gender, and week of symptom onset. Both fixed-effects and random-effects models were used in the meta-analysis. Results: Four thousand four hundred and ninety-four subjects were included. The proportion of influenza test-positive subjects across the five seasons was 11.5% (132/1151), 7.2% (41/572), 23.9% (189/791), 6.6% (75/1135), and 11.2% (95/845), respectively. The pooled VE was 62% (95% confidence interval (CI) 48-83%) in both meta-analysis models. By age category, VE was 51% (95% CI 23-68%) for those aged 6-23 months and 75% (95% CI 60-84%) for those aged 24-59 months. Conclusions: Influenza vaccination provided measurable protection against laboratory-confirmed influenza among children aged 6-59 months despite variations in the vaccine match during the 2004/2005 to 2008/2009 influenza seasons in Taiwan. ? 2014 The Authors.Case-control studies; Influenza surveillance; Influenza vaccine effectiveness[SDGs]SDG3influenza vaccine; influenza vaccine; age; Article; case control study; child; controlled study; disease surveillance; drug efficacy; female; flu like syndrome; gender; human; infant; infection prevention; influenza; influenza vaccination; major clinical study; male; meta analysis (topic); physician; preschool child; register; season; Taiwan; throat culture; virus isolation; winter; epidemiological monitoring; immunology; Influenza A virus; Influenza, Human; meta analysis; statistical model; Case-Control Studies; Child, Preschool; Epidemiological Monitoring; Female; Humans; Infant; Influenza A virus; Influenza Vaccines; Influenza, Human; Logistic Models; Male; Seasons; Taiwanjournal article10.1016/j.ijid.2014.11.011254621802-s2.0-84918562947