Yang, Yi-ChiehYi-ChiehYangHo, Kuo-HaoKuo-HaoHoKUO-TAI HUAChien, Ming-HsienMing-HsienChien2025-03-042025-03-042024-11https://scholars.lib.ntu.edu.tw/handle/123456789/725436The KH-type splicing regulatory protein (KHSRP), also known as KSRP, is an RNA-binding protein that regulates gene expressions through various mechanisms, including messenger (m)RNA degradation, micro (mi)RNA maturation, and transcriptional activity. KSRP has been implicated in a wide range of physiological and pathological processes, with emerging evidence highlighting its role in modulating diverse aspects of cancer behaviors. In this review, we provide a comprehensive overview of KSRP's clinical relevance and its multifaceted regulatory mechanisms in cancer. Our extensive pan-cancer analysis uncovers associations of KSRP with clinical outcomes and identifies cell cycle progression as a key signaling pathway correlated with KSRP expression. Furthermore, we identify miR-17-5p as critical miRNAs positively correlated with KSRP, and it is associated with poor survival in various cancers. Collectively, this review offers new insights into the potential of KSRP as a target for therapeutic strategies in cancer treatment.enCancer progressionKSRPRNA-binding proteinmRNA stabilitymiRNA maturation[SDGs]SDG3journal article10.1016/j.bbcan.2024.18920239447687