Utilizing High-Throughput Screening Data, Integrative Toxicological Prioritization Index Score, and Exposure–Activity Ratios for Chemical Prioritization: A Case Study of Endocrine-Active Pesticides in Food Crops

YU-SYUAN LUOWu, Tsung HsienTsung HsienWu2021-09-162021-09-1620210021-85611520-5118https://scholars.lib.ntu.edu.tw/handle/123456789/583002Endocrine-active chemicals can directly act on nuclear receptors and trigger the disturbances of metabolism and a homeostatic system, which are important risk factors for complicating chronic diseases in humans. The endocrine-active potentials of pesticid[SDGs]SDG3Diagnosis; Endocrine disrupters; Health risks; Pesticides; Risk assessment; Stochastic models; Chemical prioritization; Dose simulations; Endocrine-active pesticide; High-throughput; Human exposures; Prioritization; Stochastic human exposure and dose simuUtilizing High-Throughput Screening Data, Integrative Toxicological Prioritization Index Score, and Exposure–Activity Ratios for Chemical Prioritization: A Case Study of Endocrine-Active Pesticides in Food Cropsjournal article10.1021/acs.jafc.1c03191