2006-08-012024-05-15https://scholars.lib.ntu.edu.tw/handle/123456789/663726摘要：在台灣及以發展國家中超過三分之一人口患有肝臟脂質浸潤的問題。而造成此一疾徵的主要因子有酒精毒性作用、糖尿病、肥胖、胰島素抗阻及病毒感染、化學毒物與代謝功能異常所引起；而脂肪肝亦是許多肝臟疾病的初始症狀。當患有肝臟脂肪浸潤疾病的患者，主要病徵為肝臟細胞脂質累積而產生細胞中含有油滴狀脂肪之型態變化。近年來脂肪肝已是世界臨床疾病上普遍且重要的課題，因此不論是酒精性或非酒精性脂肪肝都是現今臨床欲開發藥物以治療的重要疾病之一。因此，針對不同型式的脂肪肝的研究便有其必要性，藉以發展更多的有效治療與預防策略。除此之外還有許多研究尚未解決問題更需要考量，包括酒精或高脂肪飲食所造成的病理與生理的變異以及肝臟細胞代謝異常的作用機制。許多的實驗動物模式已應用於探討酒精或飼糧對於脂肪肝原因的研究，其目的便在盡可能模擬人類疾病狀況下來建立的動物模式，藉以尋求最佳的脂肪肝動物模式。因此本研究的主要目的便是在一年內建立最佳的脂肪肝動物模式以供相關藥品或食品研發的脂肪肝動物模式。此計畫的主要目標為：1. 建立酒精性脂肪肝動物模式。 2. 建立非酒精性脂肪肝動物模式。<br> Abstract: Hepatic steatosis is present in up to one third of the population of the Taiwan and other developed countries. The etiopathogenic factors are diverse and include alcohol intoxication, diabetes mellitus, obesity, insulin resistance, and viral, chemical toxic and metabolism disorder. Fatty liver (hepatic steatosis) is the earliest stage of alcoholic liver disease. In patients with steatosis, lipid accumulates in lipid droplets within hepatocytes. Fatty liver disease is one of the most common causes of chronic liver disease in the world. Patients with alcoholic or non-alcoholic fatty liver play an important role in clinical medicine. One can easily recognize that there is an enormous need for alcoholic or non-alcoholic research in gastroenterology to develop more effective strategies to prevent and treat the different kinds of fatty liver disease. Additionally, a considerable number of open questions remain in the field of fatty liver disease research; among them important issues include the pathophysiology of ethanol or high fat diet-induced cell damage, the action of the hepatic metabolism disorder. Animal models have been employed to mimic the human situation and to simplify studies on the effects of food or drugs on the fatty liver disease animal model. With the long term goal of an ideal fatty liver disease animal model, this proposal attempts to accomplish the follow two specific aims during the one year. 1. To establish animal model of the alcoholic fatty liver disease. 2. To set up and characterize animal model of the non-alcoholic fatty liver disease.酒精性脂肪肝非酒精性脂肪肝alcoholic fatty liver disease (AFLD)non-alcoholic fatty liver disease (NAFLD)