CHE-MING TENG2018-09-102018-09-101996http://www.scopus.com/inward/record.url?eid=2-s2.0-0029893992&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/320351Members of a series of benzylisoquinoline and phenanthrene alkaloids were tested for their antiplatelet and vasorelaxing actions. Atherosperminine HClO4 (15) and atherosperminium I (16) showed strong inhibition of adenosine 5'-diphosphate-induced platelet aggregation. dl-N- Methylcoclaurine (1), dl-coclaurine (6), 15, 16, xylopine hydroxylamine (18), and atherosperminine N-oxide (19) showed strong inhibition of arachidonic acid-induced platelet aggregation. Compounds 1, 15, 16, dicentrine methine (17), 18, and 19 showed strong inhibition of collagen- induced platelet aggregation. d-(-)-Magnocurarine I (8), 15, and 16 showed strong inhibition of platelet-activating factor-induced platelet aggregation. Compounds 15, 17, and 19 showed vasorelaxing action in rat thoracic aorta.[SDGs]SDG3armepavine; benzylisoquinoline derivative; coclaurine; dicentrine; glaucine; laudanosine; phenanthrene derivative; reticuline; xylopine; animal cell; arachidonic acid metabolism; article; atherosclerosis; blood clot lysis; cardiovascular disease; drug effect; nonhuman; rabbit; thrombocyte aggregation; thrombosis; vascular smooth muscle; vasodilatation; Alkaloids; Animals; Aorta, Thoracic; Female; Muscle Relaxation; Muscle, Smooth, Vascular; Platelet Aggregation Inhibitors; Rabbits; Rats; Vasodilator Agents; Animalia; Oryctolagus cuniculusjournal article10.1021/np960354x