Cheng B.-H.Sheen L.-Y.SHANG-TZEN CHANG2019-07-112019-07-11201522254110https://scholars.lib.ntu.edu.tw/handle/123456789/413538Cinnamomum osmophloeum ct. linalool (rou gu?) is one chemotype of the indigenous cinnamons in Taiwan. This study examined the anxiolytic potency of leaf essential oil (LEO) from C. osmophloeum ct. linalool and its main constituent on 4-week ICR mice using an open field test (OFT), a lightedark test (LDT) and an elevated plus maze test (EPT). After oral administration of corn oil, LEO (250 mg/kg and 500 mg/kg), S-(+)-linalool (500 mg/kg), R-(-)-linalool (500 mg/kg), and trazodone hydrochloride (75 mg/kg) for 14 days, the anxiolytic effects on mice behavior were evaluated. The results showed that LEO from C. osmophloeum ct. linalool leaves and S-(+)-linalool can significantly increase the time mice remained in the center area of the OFT, the illuminated area of the LDT and the open arms of the EPT without any side effects affecting motor activity, indicating excellent anxiolytic responses. Furthermore, results from the measurements of monoamines in mice brain revealed decreases in serotonin, dopamine, and norepinephrine, which are consistent with their anxiolytic effects in animal models. The findings obtained suggest that LEO from C. osmophloeum ct. linalool and its major compound, S-(+)-linalool, possess anxiolytic properties without any side effects and thus support their potential use in treatment of anxiety disorders. ? 2015, Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.anxiolytic activityCinnamomum osmophloeum ct. linaloolleaf essential oilmonoaminesS-(+)-linalooljournal article10.1016/j.jtcme.2014.10.007https://www.scopus.com/inward/record.uri?eid=2-s2.0-84940165168&doi=10.1016%2fj.jtcme.2014.10.007&partnerID=40&md5=9a48ce1cea04675df3191646c468bb7c2-s2.0-84940165168https://www.scopus.com/inward/record.uri?eid=2-s2.0-84940165168&doi=10.1016%2fj.jtcme.2014.10.007&partnerID=40&md5=9a48ce1cea04675df3191646c468bb7c