SUI-YUAN CHANGHSIN-YUN SUNJi D.-D.Lo Y.-C.Wu C.-H.Wu P.-Y.Liu W.-C.CHIEN-CHING HUNGSHAN-CHWEN CHANG2020-06-182020-06-1820080095-1137https://scholars.lib.ntu.edu.tw/handle/123456789/503563Among 345 persons who underwent indirect hemagglutination (IHA) serological assays and assays of specific amebic antigens in their stool samples, 24 of 36 (66.7%) who were seropositive for Entamoeba histolytica had intestinal amebiasis as determined by antigen assays compared with 2 of 309 (0.2%) who were seronegative (odds ratio, 307; 95% confidence interval, 64.9 to 1,451). The estimated cost to detect a case of intestinal amebiasis by serology followed by antigen assays ($52) could be reduced by 74.3% and 69.9%, respectively, compared with the costs of the concurrent use of both assays ($202) and the antigen assays alone ($173). Our finding suggests that IHA assays followed by specific-amebic-antigen assays can be cost-effective in the diagnosis of intestinal amebiasis among persons with or without human immunodeficiency virus infection who are at risk for E. histolytica infection. Copyright ? 2008, American Society for Microbiology. All Rights Reserved.[SDGs]SDG3adolescent; adult; aged; article; cost effectiveness analysis; dysentery; Entamoeba histolytica; feces analysis; female; hemagglutination test; human; Human immunodeficiency virus infection; immunoassay; infection risk; major clinical study; male; priority journal; serology; Adolescent; Adult; Aged; Aged, 80 and over; AIDS-Related Opportunistic Infections; Animals; Antigens, Protozoan; Cost-Benefit Analysis; Costs and Cost Analysis; Dysentery, Amebic; Entamoeba histolytica; Hemagglutination Tests; Humans; Male; Middle Aged; Seroepidemiologic Studies; Taiwan; Young Adult; Entamoeba histolytica; Human immunodeficiency virusjournal article10.1128/JCM.01151-08185961422-s2.0-53649110113