Su M.-C.RAY-HWANG YUANLin C.-Y.YUNG-MING JENG2020-03-062020-03-0620080893-3952https://www.scopus.com/inward/record.uri?eid=2-s2.0-57749109121&doi=10.1038%2fmodpathol.2008.107&partnerID=40&md5=bed8ac4822782e221f031673d804fb29https://scholars.lib.ntu.edu.tw/handle/123456789/473427Cadherin-17, also called liver-intestine cadherin, is a calcium-dependent transmembrane glycoprotein that mediates cell-cell adhesion in intestinal epithelium. Expression of cadherin-17 was reported in gastric, pancreatic, and colorectal adenocarcinomas but not in other tumors. Whether cadherin-17 can be used as a marker for diagnosis of cancers is still unclear. In this study, we used immunohistochemical methods to stain cadherin-17 in tissue arrays containing most normal tissues and 518 carcinomas from many anatomic sites. Among normal tissues, the expression of cadherin-17 was limited to epithelial cells of small intestine and colon. Colorectal adenocarcinomas showed staining in 96% of cases and most of them had strong and diffuse staining. Gastric, pancreatic, and biliary adenocarcinomas showed diffuse or scattered staining in about 25-50% of cases. Fewer than 1% of carcinomas outside the digestive system were positive for cadherin-17. When a two-marker, Cadherin-17/cytokeratin 7, profile was used, 37 of 38 (97%) cadherin-17(+)/cytokeratin 7(-) tumors were colorectal adenocarcinomas; 49 of 56 (86%) cadherin-17(+)/cytokeratin 7(+) tumors were gastric, pancreatic, or biliary adenocarcinomas. Our results show that cadherin-17 is a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system. ? 2008 USCAP, Inc All rights reserved.[SDGs]SDG3cadherin 17; cadherin 7; cytokeratin 7; glycoprotein; unclassified drug; article; cancer diagnosis; colorectal carcinoma; controlled study; histopathology; human; human tissue; major clinical study; pancreas adenocarcinoma; priority journal; protein expression; stomach adenocarcinoma; Adenocarcinoma; Cadherins; Colorectal Neoplasms; Female; Gastrointestinal Neoplasms; Humans; Immunoenzyme Techniques; Male; Pancreatic Neoplasms; Stomach Neoplasms; Tumor Markers, Biologicaljournal article10.1038/modpathol.2008.107185528202-s2.0-57749109121