Peng C.-L.Lai P.-S.Chang C.-C.PEI-JEN LOUMING-JIUM SHIEH2020-10-272020-10-2720100143-7208https://www.scopus.com/inward/record.uri?eid=2-s2.0-69349084189&doi=10.1016%2fj.dyepig.2009.07.008&partnerID=40&md5=27145e6bb558ee559684c44e1b68fce1https://scholars.lib.ntu.edu.tw/handle/123456789/518279A series of asymmetric porphyrins with varying substituents, such as 4-hydrophenyl and N-methyl-4-pyridyl, were synthesized and characterized and their cell uptake, intracellular localization, cytotoxicities and phototoxicities were evaluated in vitro. The most phototoxic of the porphyrins synthesized, 5,10-di-(N-methyl-4-pyridyl)-15,20-(4-hydroxyphenyl)-21,23H-porphyrin, which was mainly localized in the mitochondria and displayed low levels of dark toxicity toward human cancer HeLa cells, offers potential application in photodynamic therapy. ? 2009 Elsevier Ltd. All rights reserved.[SDGs]SDG3Asymmetric porphyrins; Cancer; Cationic porphyrin; Cell uptake; HeLa cell; Human cancer; In-vitro; Intracellular localization; Low level; Partition coefficients; Potential applications; Pyridyl; Synthesis; Cell membranes; Derivatives; Mitochondria; Optical materials; Plasmons; Porphyrins; Synthesis (chemical); Photodynamic therapy; chemical analysis; chemical compound; chemical reaction; disease; synthesis; toxicityjournal article10.1016/j.dyepig.2009.07.0082-s2.0-69349084189