MIN-TSUN LIAOCHUN-KAI CHENTING TSE LINCheng, Li-YingLi-YingChengTing, Hong-WenHong-WenTingWang, Rou-FangRou-FangWangLiu, Zhi-JunZhi-JunLiuYEN BIN LIU2023-04-132023-04-132019-12-312077-0383https://scholars.lib.ntu.edu.tw/handle/123456789/630183Atrial fibrillation (AF) is responsible for significant morbidity and mortality in patients with heart failure (HF). Modern pacemakers provide an index of intrathoracic fluid status (OptiVol fluid index-OVFI) by measuring daily intrathoracic impedance. This study aimed to determine whether OVFI is associated with increased atrial tachycardia/fibrillation (AT/AF) events in patients with a preserved ejection fraction (EF). We retrospectively reviewed data from patients with Medtronic Advisa pacemakers between 2012 and 2014 in our hospital. The association and temporal relationship between OVFI and AT/AF events were determined. A total of 150 patients with 211 follow-up visits (mean 1.4 visits per patient) were evaluated. The device-detected AT/AF prevalence was 47%. Device-measured OVFI ≥ 20 Ω-days was significantly associated with the onset of AT/AF ≥ 4 h. OVFI threshold crossing preceded AT/AF events in 55.1% of cases, followed by AT/AF events in only 18.7%. Fluid overload represented by OVFI may trigger AT/AF episodes in patients with a preserved EF more often than that previously reported in patients with a reduced EF. Our findings support the view that worsening pulmonary congestion is associated with increased AT/AF frequency and suggests that fluid overload could trigger and perpetuate AT/AF events in patients with a preserved EF.enOptiVol fluid indexatrial tachyarrhythmiasintrathoracic impedance[SDGs]SDG3journal article10.3390/jcm9010105319061032-s2.0-85114280911WOS:000515388400105