TZONG-HUEI LEEChen, Chien-ChihChien-ChihChenChen, Jih-JungJih-JungChenLiao, Hui-FenHui-FenLiaoChang, Hsun-ShuoHsun-ShuoChangSung, Ping-JyunPing-JyunSungTseng, Mei-HweiMei-HweiTsengWang, Sheng-YangSheng-YangWangKo, Horng-HueyHorng-HueyKoKuo, Yueh-HsiungYueh-HsiungKuo2018-09-102018-09-10201414203049http://www.scopus.com/inward/record.url?eid=2-s2.0-84919725598&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/386682The solid-state cultured products of Antrodia camphorata as health foods has been blooming for the past few decades in Taiwan. In continuing our studies on the chemical constituents of the solid-state cultured products of this fungus, 6-methoxy-4-methyl-2,3-(methylenedioxy)phenol (1) and 4,4′-(ethane-1,2-diyl)bis(2,3,6-trimethoxyphenol)(2) together with 2,3,6-trimethoxy-4-methylphenol (3), 1(10→6)abeo-ergosta-5,7,9,22-tetraen-3α-ol (4), citreoanthrasteroid B (5) and dankasterones A (6) and B (7) were purified by a series of column chromatography. Their structures were elucidated by spectral data analysis. For bioactivity assay, compounds 4-7 showed significant cytotoxicity toward murine colorectal CT26 and human leukemia K562 cancer cell lines with IC50 values ranging from 6.7 to 15.3 μM and from 12.5 to 23.1 μM, respectively. ? 2014 by the authors; licensee MDPI, Basel, Switzerland.Abeo-ergostane; Antrodia camphorata; Cytotoxicity; Dihydrostilbene; Phenylmethanoid[SDGs]SDG3antineoplastic agent; staurosporine; animal; Antrodia; chemistry; drug screening; human; IC50; isolation and purification; K562 cell line; mouse; Animals; Antineoplastic Agents; Antrodia; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; K562 Cells; Mice; Staurosporinejournal article10.3390/molecules191221378255328372-s2.0-84919725598