Tsai W.-J.Lin J.-Y.YAO-HSU YANGJYH-HONG LEEBOR-LUEN CHIANG2021-07-022021-07-0220091684-1182https://www.scopus.com/inward/record.uri?eid=2-s2.0-70349909790&partnerID=40&md5=4f1396c2a6c66efac30da54dfc60613bhttps://scholars.lib.ntu.edu.tw/handle/123456789/567913Background and purpose: Primary hypogammaglobulinemia has been proposed to be associated with an increased incidence of allergic diseases, but the correlation between the clinical presentation and the serum immunoglobulin E (IgE) level has not been studied in this patient group. This study investigated the correlation of IgE levels and allergic condition in patients with primary hypogammaglobulinemia. Methods: Thirty five patients with primary hypogammaglobulinemia were enrolled from September 2004 to March 2005. Serum IgE levels were measured at clinic follow-up. Information regarding the patient's history of allergic diseases, including atopic dermatitis, allergic rhinitis, allergic conjunctivitis, and asthma, were collected from chart review and clinic interviews. Results: Significantly lower mean ± standard deviation serum IgE levels were found in allergic patients with primary hypogammaglobulinemia (123.9 ± 148.8 lU/mL) than in the healthy control group (376.2 ± 471.7 lU/mL) [p < 0.005] or in allergic patients without primary hypogammaglobulinemia (544.1 ± 309.1 lU/mL) [p < 0.001]. Conclusions: Serum IgE level is not a suitable diagnostic criterion or treatment guide for allergy in patients with primary hypogammaglobulinemia. ? 2009 Journal of Microbiology, Immunology and Infection.[SDGs]SDG3immunoglobulin E; allergic asthma; allergic conjunctivitis; allergic rhinitis; article; atopic dermatitis; child; clinical article; controlled study; female; human; immunoglobulin blood level; immunoglobulin deficiency; male; school child; Taiwan; tertiary health care; Adolescent; Agammaglobulinemia; Child; Child, Preschool; Female; Hospitals; Humans; Hypersensitivity; Immunoglobulin E; Male; Statistics, Nonparametric; Taiwan; Young Adultjournal article198128622-s2.0-70349909790