婦產科CAUCHI MAURICE N.COULAM CAROLYN B.COWCHOCK SUSANHO, HONG-NERNGHONG-NERNGHOGATENBY PAULJOHNSON PETER M.LUBS MARIE LOUISE E.MCINTYRE JONE A.RAMSDEN GORDON H.SMITH J. BRUCESHARPE KEN2009-01-192018-07-122009-01-192018-07-121995http://ntur.lib.ntu.edu.tw//handle/246246/99260　　Problem: Compare data from several centers relating to success rates in recurrent spontaneous miscarriage and assess the significance of indicators of subsequent pregnancy loss. Method: Data from 777 couples with unexplained recurrent spontaneous abortion from individual 　studies at seven centers were analyzed using logistic regression analysis. The following covariates: age of patient, number of previous spontaneous abortions, length of previous abortions history, sub- infertility index (defined as the product of the number of spontaneous abortions and the abortion history), whether a patient was a primary or secondary aborter, and whether a patient had received leukocyte immunotherapy. Results: There was a highly significant difference between the seven centers in success rates in the subseqhent pregnancy and a highly significant association between success rate and each of the following covariates: the number of previous spontaneous abortions, the length of the previous abortion history and sub- infertility index. In particular, for each increase of 10 units in the value of the sub- infertility index, up to a value of 30, the odds in favor of a successful pregnancy decreased by a factor of 0.6, i.e. , 40% . There was, however, little evidence of an association　between the success rate in the subsequent pregnancy and age, parity, or immunization with cells from the husband. Conclusions: The sub-infertility index may be a useful measure of likelihood of success in a subsequent pregnancy. #1848#en-US