YUAN LUOTseng, Ming LunMing LunTsengVyas, SunilSunilVyasKuo, Hsin YuHsin YuKuoChu, Cheng HungCheng HungChuChen, Mu KuMu KuChenHsiang-Chieh LeeWEN-PIN CHENSu, Vin-CentVin-CentSuShi, XuXuShiMisawa, HiroakiHiroakiMisawaTsai, Din PingDin PingTsaiPAN-CHYR YANG2022-04-272022-04-272022-042366-9608https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125187854&doi=10.1002%2fsmtd.202101228&partnerID=40&md5=b20706d432598daee8e5be4ea231f13fManipulation and precise delivery of optical energies in the regions of interest within specimens require different strategies. Hence, proper control of input beam parameters is a prerequisite. One of the prominent methods is metasurface optics, capable of crafting properties of light at nanoscales. Here, the generation of an abrupt autofocusing (AAF) beam by a nanophotonic metasurface for biomedical applications is demonstrated. Fluorescence guided laser microprofiling of mouse cardiac samples is experimentally investigated, using the AAF beam to deliver optical energy selectively to specific locations. In addition, photocoagulation of ex vivo swine skin tissue is performed and observed through optical coherence tomography. The results show great potentials for integrating metasurface optics to realize miniature laser surgery instruments for wide applications in biomedicine.enabrupt autofocusing beam; laser surgery; metasurfaces[SDGs]SDG7Medical applications; Optical tomography; Abrupt autofocusing beam; Auto-focusing; Beam parameter; Biomedical applications; Metasurface; Nano scale; Optical energy; Property; Region-of-interest; Regions of interest; Laser surgery; animal experiment; animal tissue; article; biomedicine; controlled study; ex vivo study; fluorescence; heart; laser coagulation; laser surgery; male; mouse; nonhuman; optical coherence tomography; optics; pig; skinjournal article10.1002/smtd.202101228352121862-s2.0-85125187854WOS:000760614900001https://scholars.lib.ntu.edu.tw/handle/123456789/601523