Chen, Wei-TingWei-TingChenYan, Chi FongChi FongYanYu, Cheng JuCheng JuYuYING-CHIH LIAOCHIEN-FU CHEN2024-04-032024-04-032024-06-1509565663https://scholars.lib.ntu.edu.tw/handle/123456789/641753Prussian blue analogues (PBAs) are promising materials due to their rich active sites and straightforward synthesis. However, their limited conductivity and electron transfer inefficiency hinder practical applications. This study utilizes a simple one-pot synthesis approach to produce a tungsten-disulfide (WS2) and iron-cobalt Prussian blue analogue composite (WS2-PBA), enhancing conductivity and electron transfer rate performance. Through the inclusion of sodium citrate into the solution, the S-edge site concentration of WS2 increases. This augmentation introduces additional active sites and defects into the catalyst, enhancing its catalytic activity. The effectiveness of the WS2-PBA 3D-Origami paper device for lactate detection in sweat is also evaluated for biomedical applications. The device demonstrated a robust relationship between the lactate concentration and current intensity (R2 = 0.997), with a detection limit of 1.83 mM. Additionally, this platform has successfully detected lactate in clinical sweat, correlating with the high-performance liquid chromatography test results, suggesting promising prospects for clinical diagnosis. In the future, the excellent catalytic and Rct performance of the WS2-PBA will enable its use in biomedical applications.enLactate | One-pot synthesis | Paper-based electrochemical sensor | Prussian blue analogues | Sweat sensor[SDGs]SDG3journal article10.1016/j.bios.2024.116188384844122-s2.0-85187715974https://api.elsevier.com/content/abstract/scopus_id/85187715974