2011-08-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/647434摘要：人類大腦對色彩的感知始自於眼球視網膜上感色錐狀細胞，訊息經由外膝狀核到紋狀皮質層，再到紋狀區外部皮質層--目前的認為是在posterior inferior temporal (PIT) complex，相當於猴子腦部V4的腦區。色彩與其他的一些表面特徵的認知，例如型態(shape)、質地(texture)一般認為是由相近區域的神經元處理，統稱為視覺傳導的ventral stream。色覺異常的人口在男性約佔百分之八，大多數的先天性色覺異常是由於視網膜上的感色錐狀細胞，大多是L錐狀細胞以及M錐狀細胞產生遺傳變異，經由性聯遺傳傳到下一代，而色覺異常者在腦區(brain mapping)的分佈以及對其他表面特徵的視知覺相對於色覺正常者有否變異，是一個還未曾被深入探討的議題。在本研究中，我們將使用腦電波和功能性核磁共振造影的實驗方法去探討色覺異常患者腦區的分佈和正常人是否不同。我們研究的方法是給予色彩視覺刺激後，以功能性核磁共振造影去確認和視覺行為作業相對應的腦區，並使用腦波儀量測和該作業行為相關的反應時間序列，再利用計算模型將神經影像的資料相結合，以了解色覺異常者在腦部皮質反應與對質地感知的變化。我們的目的是期望能夠測量和這些視覺行為相關的腦部活動，以瞭解色覺功能傳導的過程和其真正的腦區分佈，和在失去部份色覺後是否其他腦部視覺功能也受到改變。<br> Abstract: Color perception processing in human brain starts from cone photoreceptors in retina. The signals project to neurons in the primary visual cortex through lateral geniculate nucleus, then further project to extrastriate visual cortex—mostly studied area is inferior temporal (PIT) complex, homologous to macaque V4. Color perception is currently regarded via ventral stream in visual processing in human brain, which dealing with surface properties such as form, texture and color.People with color vision deficiency constitute about 8% in male, most of them were X-linked inherited with genetic variation in genes coding in L- and M-cone photoreceptors. However, the retinotopic mapping in subjects with color vision deficiency as well as their perception to texture has not fully investigated yet. It is of interest to study the retinotopic mapping using modern technology such as magnetic resonance imaging (fMRI).In this study, we are going to apply event related potential (ERP) and fMRI to investigate this issue in subjects with color deficiency. After designing the visual color stimulus, we will to study the performance correlated fMRI activation to identify the relevant brain areas and ERP voltage change to identify their temporal and spatial dynamics. The current density analysis will also be applied to associate ERP and fMRI and evaluate the differences of cortical responses between normal subjects and subjects with color vision deficiency.功能性核磁共振色盲色弱fMRIcolor vision deficiency