Chyuan, I-TsuI-TsuChyuanLiao, Hsiu-JungHsiu-JungLiaoTan, Tse-HuaTse-HuaTanChuang, Huai-ChiaHuai-ChiaChuangChu, Yu-ChuanYu-ChuanChuPan, Meng-HsunMeng-HsunPanWu, Chien-ShengChien-ShengWuCHING-LIANG CHUBOR-CHING SHEUPING-NING HSU2024-04-262024-04-262024-03-2710217770https://scholars.lib.ntu.edu.tw/handle/123456789/642047T cell receptor (TCR) signaling and T cell activation are tightly regulated by gatekeepers to maintain immune tolerance and avoid autoimmunity. The TRAIL receptor (TRAIL-R) is a TNF-family death receptor that transduces apoptotic signals to induce cell death. Recent studies have indicated that TRAIL-R regulates T cell-mediated immune responses by directly inhibiting T cell activation without inducing apoptosis; however, the distinct signaling pathway that regulates T cell activation remains unclear. In this study, we screened for intracellular TRAIL-R-binding proteins within T cells to explore the novel signaling pathway transduced by TRAIL-R that directly inhibits T cell activation.enPhosphatase; SHP-1; T cell receptor signaling; TRAIL receptor[SDGs]SDG3journal article10.1186/s12929-024-01023-8385324232-s2.0-85188646547