醫療機構管理所CHEN, HUNG-CHIHUNG-CHICHENSU, SYISYISU2010-06-102018-06-292010-06-102018-06-292009http://ntur.lib.ntu.edu.tw//handle/246246/185448Entry lesions at file toes interdigital spaces, in the setting of chronic lymphedema, are strongly associated with repetitive infective episodes which cause significant morbidity. A prospective Study was designed to evaluate the outcome in 2 groups of patients affected by end stage III lymphedema of the lower extremity. treated with the Charles procedure with or Without simultaneous amputation of the toes. At a mean 3 years of follow-up, 20% of the patients receiving elective toes amputation experienced recurrence of the infection and none required more proximal amputations. Among file patients not desiring elective toes amputation; 83 % suffered multiples attacks of cellulitis and in 88% the toes were eventually amputated. The difference in the number of infective episodes between file 2 groups was highly significant. No cases Of recurrent lymphedema were registered. Elective toes amputation in combination with the Charles procedure reduces recurrent cellulitis and long- term morbidity in stage III lymphedema of the lower leg.en-USCharles procedurelymphedematoes amputationlimb salvagejournal article10.1016/S0749-4041(09)79257-7