Chiu, Chong-ChiChong-ChiChiuHo, Chung-HanChung-HanHoHung, Chao-MingChao-MingHungChao, Chien-MingChien-MingChaoLai, Chih-ChengChih-ChengLaiChen, Chin-MingChin-MingChenLiao, Kuang-MingKuang-MingLiaoWang, Jhi-JoungJhi-JoungWangWu, Yu-CihYu-CihWuShi, Hon-YiHon-YiShiPO-HUANG LEELee, Hui-MingHui-MingLeeYeh, Li-RenLi-RenYehSoong, Tien-ChouTien-ChouSoongChiang, Shyh-RenShyh-RenChiangCheng, Kuo-ChenKuo-ChenCheng2023-07-132023-07-132021-07-172072-6694https://scholars.lib.ntu.edu.tw/handle/123456789/633570It has been acknowledged that excess body weight increases the risk of colorectal cancer (CRC); however, there is little evidence on the impact of body mass index (BMI) on CRC patients' long-term oncologic results in Asian populations. We studied the influence of BMI on overall survival (OS), disease-free survival (DFS), and CRC-specific survival rates in CRC patients from the administrative claims datasets of Taiwan using the Kaplan-Meier survival curves and the log-rank test to estimate the statistical differences among BMI groups. Underweight patients (<18.50 kg/m2) presented higher mortality (56.40%) and recurrence (5.34%) rates. Besides this, they had worse OS (aHR:1.61; 95% CI: 1.53-1.70; p-value: < 0.0001) and CRC-specific survival (aHR:1.52; 95% CI: 1.43-1.62; p-value: < 0.0001) rates compared with those of normal weight patients (18.50-24.99 kg/m2). On the contrary, CRC patients belonging to the overweight (25.00-29.99 kg/m2), class I obesity (30.00-34.99 kg/m2), and class II obesity (≥35.00 kg/m2) categories had better OS, DFS, and CRC-specific survival rates in the analysis than the patients in the normal weight category. Overweight patients consistently had the lowest mortality rate after a CRC diagnosis. The associations with being underweight may reflect a reverse causation. CRC patients should maintain a long-term healthy body weight.enbody mass indexcolorectal cancercolorectal cancer-specific survivaldisease-free survivaloncologic prognosisoverall survivaljournal article10.3390/cancers13143592342988052-s2.0-85110112391https://api.elsevier.com/content/abstract/scopus_id/85110112391