Sheen T.-SHsu Y.-HJENG-YUH KO2021-11-182021-11-1819981016-3190https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031807654&partnerID=40&md5=fc178b4766753ffa2afe12c560a77efehttps://scholars.lib.ntu.edu.tw/handle/123456789/587212Pyogenic granulomas are common benign tumors which generally occur in the head and neck region. The most common site of occurrence is the gingiva of the oral cavity. Trauma and hormone imbalance have been proposed as etiologies. Oral pyogenic granulomas are usually small because the patients themselves can easily detect these lesions. We report the case of a 54-year- old mentally retarded woman who presented with a large oral tumor on her hard palate. This 5 x 4 cm cauliflower-like pink tumor was firm with a pedicle originating from the dental socket of her left upper molar. It was excised and the gingival defect was covered with a local rotational palatal flap. The histopathology revealed a pyogenic granuloma with extensive fibrosis, indicating a long-term process. She has receivedfollow-up examination for 3 years with no recurrence of the tumor. Large oral pyogenic granulomas are unusual and should be considered in the differential diagnosis of a malignant oral tumor. Complete surgical removal of the tumor and subsequent covering of the area with a local palatal flap can prevent recurrence.Lobular capillary hemangioma; Oral tumor; Pyogenic granuloma[SDGs]SDG3adult; article; cancer surgery; case report; differential diagnosis; female; hard palate; histopathology; human; mental deficiency; mouth tumor; pyogenic granulomajournal article2-s2.0-0031807654