婦產科WU, MEI-HSUANMEI-HSUANWUCHOU, YU-CHINGYU-CHINGCHOUYU, JYH- CHERNGJYH- CHERNGYUCHU, CHI-MINGCHI-MINGCHUHSIEH, CHANG-YAOCHANG-YAOHSIEHYOU, SAN-LINSAN-LINYOUCHEN, CHIEN-JENCHIEN-JENCHENSUN, CHIEN-ANCHIEN-ANSUN2008-12-242018-07-122008-12-242018-07-122006http://ntur.lib.ntu.edu.tw//handle/246246/93941PURPOSE: This prospective cohort study of 11,889 women was conducted to determine significant factors associated with the risk of breast cancer among Chinese women in Taiwan, a low-incidence area. METHODS: In-person interviews were completed for subjects to solicit information on hormonal factors. Measurements of height, weight, and waist-and-hip circumferences were performed by well-trained assistants using standardized techniques. Cox proportional hazards models were employed to estimate relative risks ( RRs) and 95 % confidence intervals (CIs). RESULTS: During an average follow-up time of 10.3 years (range: 1 to 11 years) with an accumulation of 134,063 person-years, 104 incident breast cancer cases were identified through data linkage with national cancer registry profile. There was a significant elevation in breast-cancer risk with increasing duration of the interval between age at menarche and age at first full- term pregnancy (FFTP). Additionally, central adiposity reflected by hip circumference was a significant predictor of breast cancer in this Chinese female population. CONCLUSIONS: The findings of this study indicated common mechanisms responsible for the higher incidence of breast cancer in Western populations may also explain the risk of breast cancer development in Taiwan, a low-incidence area.en-USbody sizebreast cancerhormonal risk factorsprospective study[SDGs]SDG3