Chen A.Li C.-N.Hsu P.-I.Lai K.-H.Tseng H.-H.PING-NING HSULo G.-H.Lo C.-C.Lin C.-K.Hwang I.-R.Yamaoka Y.Chen H.-C.2021-02-022021-02-0220040269-2813https://www.scopus.com/inward/record.uri?eid=2-s2.0-3242878898&doi=10.1111%2fj.1365-2036.2004.01826.x&partnerID=40&md5=a49a81934489d3f7004fcd988fd47255https://scholars.lib.ntu.edu.tw/handle/123456789/545347Background: The host genetic factors that determine the clinical outcomes of Helicobacter pylori-infected individuals remain unclear. Aim: To elucidate the risks of host interleukin-1 (IL-1) genetic polymorphisms and H. pylori infection in the development of gastric cancer. Methods: In a case-control study of 164 controls and 142 patients with gastric cancer, the IL-1B-511 biallelic polymorphisms and the IL-1RN penta-allelic variable number of tandem repeats were genotyped. Results: The carriage of IL-1RN*2, male gender, old age and H. pylori infection independently increased the risk of gastric cancer, with odds ratios of 3.3 [95% confidence interval (CI), 1.4-7.7], 2.1 (95% CI, 1.2-3.8), 5.3 (95% CI, 3.1-9.0) and 2.2 (95% CI, 1.3-3.8), respectively. H. pylori-infected individuals who were carriers of IL-1RN*2 showed increased risks of both intestinal and diffuse types of gastric cancer, with odds ratios of 11.0 and 8.7, respectively. In addition, these individuals also had a higher score of intestinal metaplasia in the corpus than did uninfected non-carriers. Conclusions: This study is the first to verify IL-1RN*2 as an independent factor governing the development of gastric cancer in Asian individuals. A combination of H. pylori testing and host genotyping may target the eradication of H. pylori to high-risk individuals.[SDGs]SDG3interleukin 1; adult; aged; article; bacterial infection; carcinogenesis; confidence interval; controlled study; female; gender; genetic polymorphism; genotype; Helicobacter pylori; human; intestine metaplasia; major clinical study; male; priority journal; risk assessment; scoring system; senescence; stomach adenocarcinoma; variable number of tandem repeat; Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Female; Helicobacter Infections; Helicobacter pylori; Humans; Interleukin-1; Male; Middle Aged; Polymorphism, Genetic; Risk Factors; Stomach Neoplasmsjournal article10.1111/j.1365-2036.2004.01826.x152337012-s2.0-3242878898