Chiu C.-Y.Feng S.-A.SHING-HWA LIUChiang M.-T.2019-11-122019-11-1220171660-3397https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025457851&doi=10.3390%2fmd15070234&partnerID=40&md5=493b4054f364f4dce7df06e67fa3de27https://scholars.lib.ntu.edu.tw/handle/123456789/431162The present study investigated and compared the regulatory effects on the lipid-related metabolism and intestinal disaccharidase/fecal bacterial enzyme activities between low molecular weight chitosan and chitosan oligosaccharide in high-fat-diet-fed rats. Diet supplementation of low molecular weight chitosan showed greater efficiency than chitosan oligosaccharide in suppressing the increased weights in body and in liver and adipose tissues of high-fat-diet-fed rats. Supplementation of low molecular weight chitosan also showed a greater improvement than chitosan oligosaccharide in imbalance of plasma, hepatic, and fecal lipid profiles, and intestinal disaccharidase activities in high-fat-diet-fed rats. Moreover, both low molecular weight chitosan and chitosan oligosaccharide significantly decreased the fecal microflora mucinase and β-glucuronidase activities in high-fat-diet-fed rats. These results suggest that low molecular weight chitosan exerts a greater positive improvement than chitosan oligosaccharide in lipid metabolism and intestinal disaccharidase activity in high-fat-diet-induced obese rats. ? 2017 by the authors. Licensee MDPI.EnglishChitosan oligosaccharide; Fecal mucinase; Fecal β-glucuronidase; Lipid metabolism; Low molecular weight chitosan[SDGs]SDG3alpha glucosidase; beta glucuronidase; chitosan; chitosan derivative; chitosan oligosaccharide; cholesterol; disaccharidase; fatty acid synthase; high density lipoprotein cholesterol; hyaluronidase; lactase; low density lipoprotein cholesterol; sucrase; triacylglycerol; unclassified drug; very low density lipoprotein cholesterol; beta glucuronidase; chitosan; hyaluronate lyase; lipid; oligosaccharide; polysaccharide lyase; adipose tissue; animal experiment; animal model; animal tissue; antidiabetic activity; Article; body weight; carbohydrate diet; controlled study; diet supplementation; dietary intake; enzyme activity; enzyme assay; enzyme linked immunosorbent assay; feces microflora; glucose regulation system; glucose transport; in vivo study; intestine flora; lipid diet; lipid metabolism; lipogenesis; liver weight; male; metabolic disorder; nonhuman; obesity; rat; weight gain; weight reduction; animal; blood; drug effects; feces; intestine; intestine flora; lipid diet; lipid metabolism; liver; metabolism; microbiology; molecular weight; Sprague Dawley rat; Adipose Tissue; Animals; Chitosan; Diet, High-Fat; Feces; Gastrointestinal Microbiome; Glucuronidase; Intestines; Lipid Metabolism; Lipids; Liver; Male; Molecular Weight; Oligosaccharides; Polysaccharide-Lyases; Rats; Rats, Sprague-Dawleyjournal article10.3390/md15070234287377082-s2.0-85025457851