Wu C.-S.CHUNG-YI HUPING-NING HSU2021-02-022021-02-0220080770-3198https://www.scopus.com/inward/record.uri?eid=2-s2.0-41949119257&doi=10.1007%2fs10067-007-0783-y&partnerID=40&md5=0b3061e703790663e84c88796d0047efhttps://scholars.lib.ntu.edu.tw/handle/123456789/545334Hepatitis C virus (HCV) infection is frequently associated with anti-SSA/Ro and anti-SSB/La autoantibodies. The objective of this study is to examine the prevalence of anti-SSA/Ro and anti-SSB/La autoantibodies in HCV-infected patients and their possible associations with HLA-DRB1 polymorphism in Chinese patients in Taiwan. About 288 HCV-infected patients were recruited for autoantibody detection and HLA-DRB1 typing. Anti-SSA/Ro and anti-SSB/La autoantibodies were detected in 12.8 and 9.7% of HCV-infected patients. Anti-SSA/Ro antibody was positively associated with age over 55 [p=0.04; odds ratio=2.17; 95% confidence interval (CI), 1.03-4.57]. Anti-SSB/La antibody was negatively associated with HLA-DR2 carriage (p=0.024; odds ratio=0.30; 95% CI, 0.10-0.90). No significant correlation was found between autoantibody production and gender, autoimmune manifestation, presence of cirrhosis, or hepatocellular carcinoma in HCV infection. In conclusion, anti-SSA/Ro and anti-SSB/La antibodies present frequently in HCV-infected patients. Anti-SSB/La antibody is negatively associated with HLA-DR2 in HCV-infected patients in Taiwan. ? 2007 Clinical Rheumatology.[SDGs]SDG3HLA DR2 antigen; La antibody; Ro antibody; antinuclear antibody; SS A antibodies; SS B antibodies; SS-A antibodies; SS-B antibodies; unclassified drug; adult; age determination; antibody detection; article; autoimmune disease; Chinese; chronic lymphatic leukemia; controlled study; female; genetic polymorphism; glomerulonephritis; goiter; Graves disease; Hashimoto disease; hematologic malignancy; hepatitis C; HLA typing; human; liver cell carcinoma; liver cirrhosis; major clinical study; male; myeloid leukemia; nonhodgkin lymphoma; prevalence; priority journal; rheumatoid arthritis; risk factor; sex ratio; Taiwan; thyroid disease; age; aged; antibody specificity; cohort analysis; genetics; hepatitis C; immunology; middle aged; Adult; Age Factors; Aged; Antibodies, Antinuclear; Antibody Specificity; Cohort Studies; Female; Hepatitis C, Chronic; HLA-DR2 Antigen; Humans; Male; Middle Aged; Polymorphism, Genetic; Taiwanjournal article10.1007/s10067-007-0783-y179924682-s2.0-41949119257