KUO-LIONG CHIENYU-KANG TUHsu, Hsiu-ChingHsiu-ChingHsuTA-CHEN SUHUNG-JU LINChen, Ming-FongMing-FongChenLee, Yuan-TehYuan-TehLee2020-09-282020-09-282012-08-171471-2261https://www.scopus.com/inward/record.uri?eid=2-s2.0-84865056929&doi=10.1186%2f1471-2261-12-66&partnerID=40&md5=e50bba38914714dc61a16e8923f5d845https://scholars.lib.ntu.edu.tw/handle/123456789/514811Background: The effects of baseline and changes in blood pressure and low density lipoprotein (LDL) cholesterol on the carotid intima media thickness (IMT) have not been well documented.Methods: A total of 2572 adults (mean age 53.8 years, 54.6% women) in a Taiwanese community undertook three blood pressure and LDL cholesterol examinations over 6 years. Latent growth curve modeling was used to investigate the effects of baseline and change in blood pressure and LDL cholesterol on IMT.Results: Greater baseline LDL and blood pressure were associated with an increase in IMT (0.005 ± 0.002 mm per 1 mg/dL [p = 0.006] and 0.041 ± 0.004 mm mmHg [p <0.0001], respectively. Change in blood pressure was associated with a significant increase in IMT (0.047±0.016, P = 0.004), whilst the association between change in LDL and change in IMT was not statistically significant (0.008±0.006, P = 0.20).Conclusions: Carotid IMT was associated with baseline blood pressure and LDL cholesterol, yet only changes of blood pressure, not LDL cholesterol, were related to carotid IMT during the 6-year observation. ? 2012 Chien et al.; licensee BioMed Central Ltd.enBlood pressure; Carotid intima media thickness; Latent growth curve modeling; LDL cholesterol[SDGs]SDG3glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; adult; arterial wall thickness; article; cardiovascular risk; carotid atherosclerosis; diagnostic imaging; ethnic group; female; glucose blood level; growth curve; human; major clinical study; male; prevalence; priority journal; systolic blood pressure; Taiwanese; Adult; Aged; Biological Markers; Blood Pressure; Carotid Artery Diseases; Carotid Intima-Media Thickness; Cholesterol, LDL; Cohort Studies; Female; Humans; Linear Models; Male; Middle Aged; Predictive Value of Tests; Prognosis; Risk Assessment; Risk Factors; Taiwan; Time Factorsjournal article10.1186/1471-2261-12-66229009062-s2.0-84865056929